{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:29:59Z","timestamp":1791509399403,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019354","name":"Azabu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["19K20452"],"award-info":[{"award-number":["19K20452"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD) is a chronic persistent intestinal disorder, with ulcerative colitis and Crohn's disease being the most common. However, the physio\u2010pathological development of IBD is still unknown. Therefore, research on the etiology and treatment of IBD has been conducted using a variety of approaches. Short\u2010chain fatty acids such as 3\u2010hydroxybutyrate (3\u2010HB) are known to have various physiological activities. In particular, the production of 3\u2010HB by the intestinal microflora is associated with the suppression of various inflammatory diseases. In this study, we investigated whether poly\u2010D\u20103\u2010hydroxybutyric acid (PHB), a polyester of 3\u2010HB, is degraded by intestinal microbiota and works as a slow\u2010release agent of 3\u2010HB. Further, we examined whether PHB suppresses the pathogenesis of IBD models. As long as a PHB diet increased 3\u2010HB concentrations in the feces and blood, PHB suppressed weight loss and histological inflammation in a dextran sulfate sodium\u2010induced IBD model. Furthermore, PHB increased the accumulation of regulatory T cells in the rectum without affecting T cells in the spleen. These results indicate that PHB has potential applications in treating diseases related to the intestinal microbiota as a sustained 3\u2010HB donor. We show for the first time that biodegradable polyester exhibits intestinal bacteria\u2010mediated bioactivity toward IBD. The use of bioplastics, which are essential materials for sustainable social development, represents a novel approach to diseases related to dysbiosis, including IBD.<\/jats:p>","DOI":"10.1096\/fj.202200919r","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T08:00:59Z","timestamp":1671782459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The novel sustained 3\u2010hydroxybutyrate donor\n                    <scp>poly\u2010D<\/scp>\n                    \u20103\u2010hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T\u2010cells"],"prefix":"10.1096","volume":"37","author":[{"given":"Rimina","family":"Suzuki","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Mishima","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-7656","authenticated-orcid":false,"given":"Masaki","family":"Nagane","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinano","family":"Mizugaki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Komuro","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuto","family":"Shimizu","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Ogata","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Aihara","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kamiie","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kamisuki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Yokaryo","sequence":"additional","affiliation":[{"name":"Okinawa Prefectural Industrial Technology Center  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Satoh","sequence":"additional","affiliation":[{"name":"School of Bioscience and Biotechnology Tokyo University of Technology  Hachioji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2002697"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680309600731"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00277"},{"key":"e_1_2_11_5_1","first-page":"116","article-title":"Short chain fatty acids as metabolic regulators of ion absorption in the colon","volume":"86","author":"Roediger WE","year":"1989","journal-title":"Acta Vet Scand Suppl"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90305-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700252RR"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08530"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12122908"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.26502\/jbb.2642-91280056"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201900132"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2019.05.038"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14785-z"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.112"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201700343"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.07.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.02.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20753"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367781780958577"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129723"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00728.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100721RR"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth894"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80068-P"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12160"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145207"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav2026"},{"key":"e_1_2_11_29_1","first-page":"492","article-title":"Efficacy of the Atkins diet as therapy for intractable epilepsy in children","volume":"13","author":"Tonekaboni SH","year":"2010","journal-title":"Arch Iran Med"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.06.011"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1995.10718495"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.09.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.00027"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R046599"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277831"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.05.013"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.728783"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00069"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1652"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.037"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202200919R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202200919R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202200919R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:14:59Z","timestamp":1791188099000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202200919R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1096\/fj.202200919R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202200919r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]},"assertion":[{"value":"2022-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22708"}}