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In the present study, we report that curcumol promotes the death of activated HSCs and reduces the deposition of extracellular matrix. Interestingly, curcumol treatment can trigger ferroptosis to eliminate activated HSCs characterized by iron overload, lipid ROS accumulation, glutathione depletion, and lipid peroxidation. Curcumol promotes HSC autophagy, which may be the key mechanism for its induction of ferroptosis. It is worth noting that the upregulation of nuclear receptor coactivator 4 (NCOA4) may play a key molecular mechanism. NCOA4 mediates the release of iron ions and induces the occurrence of ferroptosis. Overall, curcumol promotes autophagy in hepatic stellate cells, mediates the degradation of NCOA4 and FTH1 complexes, releases iron ions, leads to iron overload, and induces ferroptosis, which may be an important mechanism for its anti\u2010hepatic fibrosis effect.<\/jats:p>","DOI":"10.1096\/fj.202200933rr","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T04:15:59Z","timestamp":1668744959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells"],"prefix":"10.1096","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7646-511X","authenticated-orcid":false,"given":"Yang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Medicine Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine  Nanning 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