{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:54:41Z","timestamp":1791190481598,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Drug\u2010induced liver injury (DILI) by acetaminophen (APAP) was one of the most challenging liver diseases. Wolfberry (\n                    <jats:italic>Lycium barbarum<\/jats:italic>\n                    L.), a traditional Chinese medicinal material and food supplement, has a potential effect on increasing the abundance of\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    (\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    ) in mice colons. However, the effect and mechanism of wolfberry remain unclear in APAP\u2010induced DILI. In this study, wolfberry promoted the proliferation of activated\u2010\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    in vitro and in vivo. For the first time, we detected that the activated\u2010\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    but not the killed\u2010\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    increased the expression level of Yes\u2010associated protein 1 (YAP1) in the liver and alleviated liver injury in APAP\u2010induced DILI mice. Mechanically,\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    improved the intestinal mucosal barrier and reduced lipopolysaccharide (LPS) content in the liver, leading to the increased expression level of YAP1. Furthermore, wolfberry increased the\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    abundance in the colon and YAP1 expression in the liver from APAP\u2010induced DILI mice, which promoted the recovery of APAP\u2010induced liver injury. Meanwhile, wolfberry combination with\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    synergistically increased AKK abundance and YAP1 expression in the liver. Our research provides an innovative strategy to improve DILI.\n                  <\/jats:p>","DOI":"10.1096\/fj.202200945r","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T08:12:01Z","timestamp":1670227921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Wolfberry enhanced the abundance of\n                    <i>Akkermansia muciniphila<\/i>\n                    by\n                    <scp>YAP1<\/scp>\n                    in mice with acetaminophen\u2010induced liver injury"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-6106","authenticated-orcid":false,"given":"Yiwei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Immunology Hebei University of Chinese Medicine  Shijiazhuang 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