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A significant increase in the number of IL\u201017A\u2010positive gamma delta (\u03b3\u03b4) T cells in the skin and enlargement of draining lymph nodes was observed. These symptoms were drastically suppressed by antibiotic treatment. Cyp4f18 is highly expressed in dendritic cells (DCs), and Cyp4f18\u2010deficient bone marrow\u2010derived dendritic cells (BMDCs) show markedly increased expression levels of cytokines such as IL\u201023 and IL\u20101\u03b2 in response to lipopolysaccharide (LPS) stimulation. Lipidomic analysis of lymph nodes and BMDCs revealed a significant decrease in a series of omega\u20103 epoxidized metabolites. Among them, 17,18\u2010dihydroxyeicosatetraenoic acid (17,18\u2010diHETE), a vicinal diol derived from EPA omega\u20103 epoxidation suppressed IL\u201023 production in LPS\u2010stimulated BMDCs in Cyp4f18\u2010deficient mice. These results demonstrate that Cyp4f18 endogenously produces omega\u20103\u2010epoxidized metabolites in the draining lymph nodes, and these metabolites contribute to skin homeostasis by suppressing the excessive activation of the IL\u201023\/IL\u201017 axis initiated by DCs.\n                  <\/jats:p>","DOI":"10.1096\/fj.202200982r","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T10:56:12Z","timestamp":1668423372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic deletion of Cyp4f18 disrupts the omega\u20103 epoxidation pathway and results in psoriasis\u2010like dermatitis"],"prefix":"10.1096","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-9356","authenticated-orcid":false,"given":"Mio","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences 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