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Resolvin D1 (RvD1) is derived from \u03c9\u20103 polyunsaturated fatty acids and is involved in the resolution phase of chronic inflammatory diseases. The aim of this study was to decipher the protective role of RvD1 via formyl peptide receptor 2 (FPR2) receptor signaling in attenuating abdominal aortic aneurysms (AAA). The elastase\u2010treatment model of AAA in C57BL\/6 (WT) mice and human AAA tissue was used to confirm our hypotheses. Elastase\u2010treated FPR2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had a significant increase in aortic diameter, proinflammatory cytokine production, immune cell infiltration (macrophages and neutrophils), elastic fiber disruption, and decrease in smooth muscle cell \u03b1\u2010actin expression compared to elastase\u2010treated WT mice. RvD1 treatment attenuated AAA formation, aortic inflammation, and vascular remodeling in WT mice, but not in FPR2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Importantly, human AAA tissue demonstrated significantly decreased FPR2 mRNA expression compared to non\u2010aneurysm human aortas. Mechanistically, RvD1\/FPR2 signaling mitigated p47\n                    <jats:sup>phox<\/jats:sup>\n                    phosphorylation and prevented hallmarks of ferroptosis, such as lipid peroxidation and Nrf2 translocation, thereby attenuating HMGB1 secretion. Collectively, this study demonstrates RvD1\u2010mediated immunomodulation of FPR2 signaling on macrophages to mitigate ferroptosis and HMGB1 release, leading to resolution of aortic inflammation and remodeling during AAA pathogenesis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202201114r","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T11:30:41Z","timestamp":1664710241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Resolution of inflammation via\n                    <scp>RvD1<\/scp>\n                    \/\n                    <scp>FPR2<\/scp>\n                    signaling mitigates Nox2 activation and ferroptosis of macrophages in experimental abdominal aortic aneurysms"],"prefix":"10.1096","volume":"36","author":[{"given":"Amanda C.","family":"Filiberto","sequence":"first","affiliation":[{"name":"Department of Surgery University of Florida  Gainesville Florida 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