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The expression of IL\u201021, IL\u201021 receptor (IL\u201021R), CD31, VEGFA, MMP\u20109, and ICAM\u20101 in skin was determined by immunohistochemistry or quantitative real\u2010time polymerase chain reaction. The serum level of IL\u201021 was measured by enzyme\u2010linked immunosorbent assay (ELISA). Then, their correlation was analyzed statistically. Human umbilical vein endothelial cells (HUVECs) cocultured with conditional medium from normal human epidermal keratinocytes (NHEKs) were treated with IL\u201021 and\/or M5 cocktail (mixture of IL\u20101\u03b1, IL\u201017A, IL\u201022, TNF\u2010\u03b1, and oncostatin M). The migration and tube formation of HUVECs were detected, and the levels of VEGFA, MMP\u20109, and ICAM\u20101 in NHEKs were measured by Western blotting or ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Increased IL\u201021 and IL\u201021R expression was observed in psoriatic sera or skin specimens, with IL\u201021R mainly locating in keratinocytes and IL\u201021 in immune cells. Pearson analysis showed significantly positive correlation between IL\u201021\/IL\u201021R and erythema scores\/microvessel density in psoriatic lesions. Moreover, the expression of proangiogenic genes, VEGFA, ICAM\u20101, and MMP\u20109 was upregulated in skins of psoriasis. Additionally, in M5 microenvironment, migration and tube formation could be magnified in HUVECs using IL\u201021 pre\u2010treated NHEK medium. Mechanically, the co\u2010stimulation of IL\u201021 and M5 to NEHKs increased the expression of ICAM\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201021 could regulate keratinocytes to secrete ICAM\u20101, thereby promoting angiogenesis in psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1096\/fj.202201709rrrr","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T07:46:24Z","timestamp":1702712784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["IL\u201021 promoting angiogenesis contributes to the development of psoriasis"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4955-099X","authenticated-orcid":false,"given":"Dan","family":"Han","sequence":"first","affiliation":[{"name":"Department of 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