{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:59:39Z","timestamp":1783508379019,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1ZIAHL006077\u201010"],"award-info":[{"award-number":["1ZIAHL006077\u201010"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The increasing incidence of cardiovascular disease (CVD) has led to a significant ongoing need to address this surgically through coronary artery bypass grafting (CABG) and percutaneous coronary interventions (PCI). From this, there continues to be a substantial burden of mortality and morbidity due to complications arising from endothelial damage, resulting in restenosis. Whilst mast cells (MC) have been shown to have a causative role in atherosclerosis and other vascular diseases, including restenosis due to vein engraftment; here, we demonstrate their rapid response to arterial wire injury, recapitulating the endothelial damage seen in PCI procedures. Using wild\u2010type mice, we demonstrate accumulation of MC in the femoral artery post\u2010acute wire injury, with rapid activation and degranulation, resulting in neointimal hyperplasia, which was not observed in MC\u2010deficient Kit\n                    <jats:sup>W\u2010sh\/W\u2010sh<\/jats:sup>\n                    mice. Furthermore, neutrophils, macrophages, and T cells were abundant in the wild\u2010type mice area of injury but reduced in the Kit\n                    <jats:sup>W\u2010sh\/W\u2010sh<\/jats:sup>\n                    mice. Following bone\u2010marrow\u2010derived MC (BMMC) transplantation into Kit\n                    <jats:sup>W\u2010sh\/W\u2010sh<\/jats:sup>\n                    mice, not only was the neointimal hyperplasia induced, but the neutrophil, macrophage, and T\u2010cell populations were also present in these transplanted mice. To demonstrate the utility of MC as a target for therapy, we administered the MC stabilizing drug, disodium cromoglycate (DSCG) immediately following arterial injury and were able to show a reduction in neointimal hyperplasia in wild\u2010type mice. These studies suggest a critical role for MC in inducing the conditions and coordinating the detrimental inflammatory response seen post\u2010endothelial injury in arteries undergoing revascularization procedures, and by targeting the rapid MC degranulation immediately post\u2010surgery with DSCG, this restenosis may become a preventable clinical complication.\n                  <\/jats:p>","DOI":"10.1096\/fj.202201745rr","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T10:57:13Z","timestamp":1686653833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mast cell activation and degranulation in acute artery injury: A target for post\u2010operative therapy"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-7372","authenticated-orcid":false,"given":"Rebecca L.","family":"Harper","sequence":"first","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"San","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Negro","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-6915","authenticated-orcid":false,"given":"Cynthia","family":"St.\u00a0Hilaire","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Bioengineering, Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibin","family":"Chen","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yu","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia I.","family":"Dmitrieva","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lanzer","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Davaine","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Schwartzbeck","sequence":"additional","affiliation":[{"name":"Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avram D.","family":"Walts","sequence":"additional","affiliation":[{"name":"Department of Medicine National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Kovacic","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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