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Here, we explored the role of cyclin D3 in the physiologic response of skeletal muscle to external stimuli and in a model of muscle degenerative disease. We show that cyclin D3\u2010null mice exhibit a further transition from glycolytic to oxidative muscle fiber type in response to voluntary exercise and an improved response to fasting. Since fast glycolytic fibers are known to be more susceptible to degeneration in Duchenne muscular dystrophy (DMD), we examined the effects of cyclin D3 inactivation on skeletal muscle phenotype in the\n                    <jats:italic>mdx<\/jats:italic>\n                    mouse model of DMD. Compared with control\n                    <jats:italic>mdx<\/jats:italic>\n                    mice, cyclin D3\u2010deficient\n                    <jats:italic>mdx<\/jats:italic>\n                    mice display a higher proportion of slower and more oxidative myofibers, reduced muscle degenerative\/regenerative processes, and reduced myofiber size variability, indicating an attenuation of dystrophic histopathology. Furthermore,\n                    <jats:italic>mdx<\/jats:italic>\n                    muscles lacking cyclin D3 exhibit reduced fatigability during repeated electrical stimulations. Notably, cyclin D3\u2010null\n                    <jats:italic>mdx<\/jats:italic>\n                    mice show enhanced performance during recurrent trials of endurance treadmill exercise, and post\u2010exercise muscle damage results decreased while the regenerative capacity is boosted. In addition, muscles from exercised cyclin D3\u2010deficient\n                    <jats:italic>mdx<\/jats:italic>\n                    mice display increased oxidative capacity and increased mRNA expression of genes involved in the regulation of oxidative metabolism and the response to oxidative stress. Altogether, our findings indicate that depletion of cyclin D3 confers benefits to dystrophic muscle, suggesting that cyclin D3 inhibition may represent a promising therapeutic strategy against DMD.\n                  <\/jats:p>","DOI":"10.1096\/fj.202201769r","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T04:17:11Z","timestamp":1686629831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cyclin\n                    <scp>D3<\/scp>\n                    deficiency promotes a slower, more oxidative skeletal muscle phenotype and ameliorates pathophysiology in the\n                    <i>mdx<\/i>\n                    mouse model of Duchenne muscular dystrophy"],"prefix":"10.1096","volume":"37","author":[{"given":"Agnese","family":"Bonato","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Cell Biology National Research Council  Monterotondo 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