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Peritoneal fibrosis is triggered by chronic inflammation induced by a variety of stimuli, including peritonitis. Exposure to PD fluid alters peritoneal macrophages phenotype. Inflammasome activation triggers chronic inflammation. First, it was determined whether inflammasome activation causes peritoneal deterioration. In the in vivo experiments, the increased expression of the inflammasome components, caspase\u20101 activity, and concomitant overproduction of IL\u20101\u03b2 and IL\u201018 were observed in a mouse model of peritoneal fibrosis. ASC\u2010positive and F4\/80\u2010positive cells colocalized in the subperitoneal mesothelial cell layer. These macrophages expressed high CD44 levels indicating that the CD44\u2010positive macrophages contribute to developing peritoneal deterioration. Furthermore, intravital imaging of the peritoneal microvasculature demonstrated that the circulating CD44\u2010positive leukocytes may contribute to peritoneal fibrosis. Bone marrow transplantation in ASC\u2010deficient mice suppressed inflammasome activation, thereby attenuating peritoneal fibrosis in a high glucose\u2010based PD solution\u2010injected mouse model. Our results suggest inflammasome activation in CD44\u2010positive macrophages may be involved in developing peritoneal fibrosis. The inflammasome\u2010derived pro\u2010inflammatory cytokines might therefore serve as new biomarkers for developing encapsulating peritoneal sclerosis.<\/jats:p>","DOI":"10.1096\/fj.202201777rrr","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:58:08Z","timestamp":1692698288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-3869","authenticated-orcid":false,"given":"Hiroyuki","family":"Kadoya","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension Kawasaki Medical School  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Nephrology and 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