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Therefore, the development of noninvasive \u03b2\u2010cell imaging is required. In this study, we investigated the utility of the\n                    <jats:sup>111<\/jats:sup>\n                    Indium\u2010labeled exendin\u20104 probe {[Lys12(111In\u2010BnDTPA\u2010Ahx)] exendin\u20104} (\n                    <jats:sup>111<\/jats:sup>\n                    In exendin\u20104) to evaluate islet graft BCM after intraportal IT. The probe was cultured with various numbers of isolated islets. Streptozotocin\u2010induced diabetic mice were intraportally transplanted with 150 or 400 syngeneic islets. After a 6\u2010week observation following IT, the ex\u2010vivo liver graft uptake of\n                    <jats:sup>111<\/jats:sup>\n                    In\u2010exendin\u20104 was compared with the liver insulin content. In addition, the in\u2010vivo liver graft uptake of\n                    <jats:sup>111<\/jats:sup>\n                    In exendin\u20104 using SPECT\/CT was compared with that of liver graft BCM measured by a histological method. As a result, probe accumulation was significantly correlated with islet numbers. The ex\u2010vivo liver graft uptake in the 400\u2010islet\u2010transplanted group was significantly higher than that in the control and the 150\u2010islet\u2010transplanted groups, consistent with glycemic control and liver insulin content. In conclusion, in\u2010vivo SPECT\/CT displayed liver islet grafts, and uptakes were corroborated by histological liver BCM.\n                    <jats:sup>111<\/jats:sup>\n                    In\u2010exendin\u20104 SPECT\/CT can be used to visualize and evaluate liver islet grafts noninvasively after intraportal IT.\n                  <\/jats:p>","DOI":"10.1096\/fj.202201787rr","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T19:55:53Z","timestamp":1678564553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Noninvasive quantitative evaluation of viable islet grafts using\n                    <scp>\n                      <sup>111<\/sup>\n                      In\n                    <\/scp>\n                    \u2010exendin\u20104\n                    <scp>SPECT<\/scp>\n                    \/\n                    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