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Gastrinomas are neuroendocrine neoplasms that overproduce the hormone gastrin and can arise sporadically or as part of the\n                    <jats:italic>MEN1<\/jats:italic>\n                    syndrome, in which mutations in the\n                    <jats:italic>MEN1<\/jats:italic>\n                    gene lead to loss or inactivation of MENIN protein. Gastrin is a peptide hormone that is primarily synthesized in the gastric antrum and stimulates the secretion of histamine from enterochromaffin\u2010like (ECL) cells and subsequently acid from parietal cells in the gastric corpus. In addition, gastrin exerts a mitogenic function primarily on ECL cells and progenitor cells in the gastric isthmus. Current studies seek to understand how\n                    <jats:italic>MEN1<\/jats:italic>\n                    mutations generate a mutant MENIN protein that abrogates its tumor suppressor function. Mutations in the\n                    <jats:italic>MEN1<\/jats:italic>\n                    gene are broadly distributed throughout its nine protein\u2010coding exons, making it difficult to correlate protein structure with its function. Although disruption of the\n                    <jats:italic>Men1<\/jats:italic>\n                    locus in mice causes functional neuroendocrine tumors in the pituitary and pancreas, gastrinomas do not develop in these transgenic animal models. Prior studies of human gastrinomas suggest that tissue\u2010specific microenvironmental cues in the submucosal foregut may contribute to tumorigenesis by reprogramming of epithelial cells toward the neuroendocrine phenotype. Accordingly, recent studies suggest that neural crest\u2010derived cells are also sensitive to reprogramming when\n                    <jats:italic>MEN1<\/jats:italic>\n                    is deleted or mutated. Thus, the goal of this report is to review our current understanding of how MENIN modulates gastrin gene expression while highlighting its role in the prevention\/suppression of neuroendocrine cell transformation.\n                  <\/jats:p>","DOI":"10.1096\/fj.202201809rr","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T13:29:34Z","timestamp":1681997374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MENIN\u2010mediated regulation of gastrin gene expression and its role in gastrinoma development"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-170X","authenticated-orcid":false,"given":"Uloma B.","family":"Elvis\u2010Offiah","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine University of Arizona  Tucson Arizona 85724 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