{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T19:15:11Z","timestamp":1763234111171,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cardiac arrest (CA) and concomitant post\u2010CA syndrome lead to a lethal condition characterized by systemic ischemia\u2013reperfusion injury. Oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) supply during cardiopulmonary resuscitation (CPR) is the key to success in resuscitation, but sustained hyperoxia can produce toxic effects post CA. However, only few studies have investigated the optimal duration and dosage of O\n                    <jats:sub>2<\/jats:sub>\n                    administration. Herein, we aimed to determine whether high concentrations of O\n                    <jats:sub>2<\/jats:sub>\n                    at resuscitation are beneficial or harmful. After rats were resuscitated from the 10\u2010min asphyxia, mechanical ventilation was restarted at an FIO\n                    <jats:sub>2<\/jats:sub>\n                    of 1.0 or 0.3. From 10\u2009min after initiating CPR, FIO\n                    <jats:sub>2<\/jats:sub>\n                    of both groups were maintained at 0.3. Bio\u2010physiological parameters including O\n                    <jats:sub>2<\/jats:sub>\n                    consumption (VO\n                    <jats:sub>2<\/jats:sub>\n                    ) and mRNA gene expression in multiple organs were evaluated. The FIO\n                    <jats:sub>2<\/jats:sub>\n                    0.3 group decreased VO\n                    <jats:sub>2<\/jats:sub>\n                    , delayed the time required to achieve peak MAP, lowered ejection fraction (75.1\u2009\u00b1\u20093.3% and 59.0\u2009\u00b1\u20095.7% with FIO\n                    <jats:sub>2<\/jats:sub>\n                    1.0 and 0.3, respectively;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05), and increased blood lactate levels (4.9\u2009\u00b1\u20090.2\u2009mmol\/L and 5.6\u2009\u00b1\u20090.2\u2009mmol\/L, respectively;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) at 10\u2009min after CPR. FIO\n                    <jats:sub>2<\/jats:sub>\n                    0.3 group had significant increases in hypoxia\u2010inducible factor, inflammatory, and apoptosis\u2010related mRNA gene expression in the brain. Likewise, significant upregulations of hypoxia\u2010inducible factor and apoptosis\u2010related gene expression were observed in the FIO\n                    <jats:sub>2<\/jats:sub>\n                    0.3 group in the heart and lungs. Insufficient O\n                    <jats:sub>2<\/jats:sub>\n                    supplementation in the first 10\u2009min of resuscitation could prolong ischemia, and may result in unfavorable biological responses 2\u2009h after CA. Faster recovery from the impairment of O\n                    <jats:sub>2<\/jats:sub>\n                    metabolism might contribute to the improvement of hemodynamics during the early post\u2010resuscitation phase; therefore, it may be reasonable to provide the maximum feasible O\n                    <jats:sub>2<\/jats:sub>\n                    concentrations during CPR.\n                  <\/jats:p>","DOI":"10.1096\/fj.202202063r","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:04:32Z","timestamp":1685444672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insufficient oxygen inhalation during cardiopulmonary resuscitation induces early changes in hemodynamics followed by late and unfavorable systemic responses in post\u2010cardiac arrest rats"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-2849","authenticated-orcid":false,"given":"Tomoaki","family":"Aoki","sequence":"first","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Wong","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Endo","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Takegawa","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Shoaib","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago J.","family":"Miyara","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishabh C.","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai","family":"Yin","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Saeki","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance B.","family":"Becker","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"},{"name":"Department of Emergency Medicine Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Health  Hempstead New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-228X","authenticated-orcid":false,"given":"Koichiro","family":"Shinozaki","sequence":"additional","affiliation":[{"name":"Feinstein Institutes for Medical Research, Northwell Health  Manhasset New York USA"},{"name":"Department of Emergency Medicine Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Health  Hempstead New York USA"},{"name":"Department of Emergency &amp; Critical Care Medicine Kindai University Faculty of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.8454"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.09.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000262"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.707"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032054"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018773"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007721"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79780-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30120-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.666735"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.01.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001771"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02759-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2022.09.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1973.35.1.85"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91246-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(94)00827-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181b8569d"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000916"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2013.01.012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.06.013"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066616658420"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000897"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.10.040"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.02.013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000228"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10090"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.12.021"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.01.022"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.473967"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.8.1679"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600234"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90058-F"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9572(94)90009-4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(99)00083-0"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.05.001"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000248455.73785.b1"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.06.027"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016730"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001297"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3526"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.05.024"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/10903127.2020.1752868"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222878110"}],"container-title":["The 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