{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:25:59Z","timestamp":1775129159162,"version":"3.50.1"},"reference-count":100,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spinal cord injury (SCI) causes severe and resistant sublesional disuse bone loss. Abaloparatide, a modified parathyroid hormone related peptide, is an FDA approved drug for treatment of severe osteoporosis with potent anabolic activity. The effects of abaloparatide on SCI\u2010induced bone loss remain undefined. Thus, female mice underwent sham or severe contusion thoracic SCI causing hindlimb paralysis. Mice then received subcutaneous injection of vehicle or 20\u2009\u03bcg\/kg\/day abaloparatide for 35\u2009days. Micro\u2010computed tomography (micro\u2010CT) analysis of the distal and midshaft femoral regions of the SCI\u2010vehicle mice revealed reduced trabecular fractional bone volume (56%), thickness (75%), and cortical thickness (80%) compared to sham\u2010vehicle controls. Treatment with abaloparatide did not prevent SCI\u2010induced changes in trabecular or cortical bone. However, histomorphometry evaluation of the SCI\u2010abaloparatide mice demonstrated that abaloparatide treatment increased osteoblast (241%) and osteoclast (247%) numbers and the mineral apposition rate (131%) compared to SCI\u2010vehicle animals. In another independent experiment, treatment with 80\u2009\u03bcg\/kg\/day abaloparatide significantly attenuated SCI\u2010induced loss in cortical bone thickness (93%) when compared to SCI\u2010vehicle mice (79%) but did not prevent SCI\u2010induced trabecular bone loss or elevation in cortical porosity. Biochemical analysis of the bone marrow supernatants of the femurs showed that SCI\u2010abaloparatide animals had 2.3\u2010fold increase in procollagen type I N\u2010terminal propeptide, a bone formation marker than SCI\u2010vehicle animals. SCI groups had 70% higher levels of cross\u2010linked C\u2010telopeptide of type I collagen, a bone resorption marker, than sham\u2010vehicle mice. These findings suggest that abaloparatide protects the cortical bone against the deleterious effects of SCI by promoting bone formation.<\/jats:p>","DOI":"10.1096\/fj.202300109rr","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T14:34:00Z","timestamp":1684852440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Abaloparatide prevents immobilization\u2010induced cortical but not trabecular bone loss after spinal cord injury"],"prefix":"10.1096","volume":"37","author":[{"given":"Karim","family":"Sahbani","sequence":"first","affiliation":[{"name":"Spinal Cord Damage Research Center James J. Peters Veterans Affairs Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangping","family":"Pan","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center James J. Peters Veterans Affairs Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mone","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Departments of Medicine The Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Pharmacologic Sciences The Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Center for Translational Medicine and Pharmacology The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Cardozo","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center James J. Peters Veterans Affairs Medical Center  Bronx New York USA"},{"name":"Departments of Medicine The Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Pharmacologic Sciences The Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Rehabilitation Medicine The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Bauman","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center James J. Peters Veterans Affairs Medical Center  Bronx New York USA"},{"name":"Departments of Medicine The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6673-7393","authenticated-orcid":false,"given":"Hesham A.","family":"Tawfeek","sequence":"additional","affiliation":[{"name":"Spinal Cord Damage Research Center James J. Peters Veterans Affairs Medical Center  Bronx New York USA"},{"name":"Departments of Medicine The Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.09.0055"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2014.08.948"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199801000-00005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200108000-00009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.08.144"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0671-6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2165"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1997.tb01916.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101922"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-010-0029-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00326-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900547"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13446"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0229-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-004-0048-6"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0494-x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-011-0118-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2549"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-006-0163-3"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.415"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.07.475"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab230"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14518"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2340\/165019771994264197202"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-2011-0702"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(97)90190-8"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-014-0602-x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101832"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3525"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2013.03.032"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10375"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090418"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.10.3003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13030"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.4.513"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00428.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.000182"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005011108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6629"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.11.8895385"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0568"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24918"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158414"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32396-7"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11846"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00503.2012"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5275.613"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2260-z"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.7.1285"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.4.1110"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-6-1309"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-3-1444"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.1.40"},{"key":"e_1_2_11_55_1","first-page":"353","article-title":"Parathyroid hormone\u2010related protein and transforming growth factor activities in an extract from a breast cancer associated with humoral hypercalcemia of malignancy","volume":"19","author":"Nagata N","year":"1989","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113794"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1988.tb02221.x"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1978"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0233"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021122"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.8.2786"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.8.1517"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4304-9"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2991"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3718"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-016-0171-1"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.10.012"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2991"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4323-6"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61120-5"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11136"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3003"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116417"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.588773"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115801"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14225"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013492108"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1614"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012290"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1805"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.07.001"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.07.010"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1973.224.6.1345"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061372"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1345"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-122"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.12.006"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1567"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-004-0519-x"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.09.017"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2012.229"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.01.025"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109036109"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2022"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/47.3.597"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9091-4"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.10.037"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.3.8119139"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.679753"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202300109RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T16:08:23Z","timestamp":1765469303000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202300109RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":100,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1096\/fj.202300109RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202300109rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2023-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22984"}}