{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:21:02Z","timestamp":1783441262151,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Little is known about the effect of the recently developed calcimimetic evocalcet (Evo) on parathyroid calcium\u2010sensing receptor (CaSR) and vitamin D receptor (VDR) expression. We examined the effects of Evo and cinacalcet (Cina) on CaSR and VDR expression in 5\/6 nephrectomized Sprague\u2013Dawley rats fed a high\u2010phosphorus diet for 4\u2009weeks to develop secondary hyperparathyroidism (SHPT). These uremic rats were divided into 4\u2009groups\u2014baseline control (Nx4W) and groups with additional treatment with either the Vehicle, Evo, or Cina for 2\u2009weeks; normal rats were used as normal controls (NC). Blood parameters and parathyroid tissue were analyzed. CaSR and VDR expression levels were determined using immunohistochemistry. The degree of kidney injury and hyperphosphatemia was similar in the uremic groups (Nx4W, Vehicle, Cina, and Evo). Serum parathyroid hormone levels were significantly higher in the Nx4W and Vehicle groups than in the NC group. This increase was significantly suppressed in the Cina and Evo groups compared with that in the Vehicle group. Serum calcium levels were significantly and equally lower in the Cina and Evo groups relative to those in the Vehicle group. CaSR expression was significantly lower in the Nx4W and Vehicle groups than in the NC group. This downregulation was of an equally lesser magnitude in the Cina and Evo groups. A similar trend was observed for VDR expression. These results indicate that Evo and Cina treatment can increase parathyroid CaSR and VDR expression in uremic rats with SHPT, which could provide better control of mineral and bone disorder markers.<\/jats:p>","DOI":"10.1096\/fj.202300209r","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T09:56:28Z","timestamp":1689674188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of evocalcet on parathyroid calcium\u2010sensing receptor and vitamin D receptor expression in uremic rats"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-5401","authenticated-orcid":false,"given":"Tomohiro","family":"Saito","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-8414","authenticated-orcid":false,"given":"Masahide","family":"Mizobuchi","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Sakai","sequence":"additional","affiliation":[{"name":"Biomedical Science Research Laboratories 1 Research Unit, R&amp;D Division Kyowa Kirin Co., Ltd.  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