{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:46:15Z","timestamp":1792431975683,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072893"],"award-info":[{"award-number":["82072893"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2020\u2010PT330\u2010003"],"award-info":[{"award-number":["2020\u2010PT330\u2010003"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    LAMA5 (laminin \u03b15) is a member of the laminin family. Despite the recent research implicating LAMA5 in cancer, the\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.collinsdictionary.com\/zh\/dictionary\/english-thesaurus\/function\">function<\/jats:ext-link>\n                    of LAMA5 has remained\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.collinsdictionary.com\/zh\/dictionary\/english-thesaurus\/uncertain\">uncertain<\/jats:ext-link>\n                    in the progression of ovarian cancer (OC). Here, we investigated the functional influences of LAMA5 knockdown on OC in vitro and in vivo. In this study, we used immunohistochemistry (IHC) analysis to detect the relative expression of LAMA5 in OC and non\u2010cancer tissues, and we analyzed its\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.collinsdictionary.com\/zh\/dictionary\/english-thesaurus\/connection\">connection<\/jats:ext-link>\n                    with the overall survival (OS) of OC patients. To prove the role of LAMA5 in cell proliferation, migration, and invasion, LAMA5 expression in OC cell lines was inhibited by lentivirus. Compared with normal fallopian tube tissue, epithelial ovarian cancer (EOC) tissue\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.collinsdictionary.com\/zh\/dictionary\/english-thesaurus\/demonstrate\">showe<\/jats:ext-link>\n                    d critically higher LAMA5 expression levels; additionally, high LAMA5 levels were a poor predictor of OS. We found that cell progression was restrained in LAMA5\u2010knockdown OC cell lines in vivo and in vitro. Finally, LAMA5 might be a\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.collinsdictionary.com\/zh\/dictionary\/english-thesaurus\/commanding\">commanding<\/jats:ext-link>\n                    inducer of the expression of epithelial\u2010mesenchymal transition (EMT) and Notch signaling pathway\u2010related markers. Together, our research indicates that LAMA5 is highly connected to OC progression as it may play a role in the EMT process through the Notch signaling pathway.\n                  <\/jats:p>","DOI":"10.1096\/fj.202300306r","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T13:21:17Z","timestamp":1690896077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["<scp>LAMA5<\/scp>\n                    promotes cell proliferation and migration in ovarian cancer by activating Notch signaling pathway"],"prefix":"10.1096","volume":"37","author":[{"given":"Bowen","family":"Diao","sequence":"first","affiliation":[{"name":"Department of Gynecology, First Affiliated Hospital Shihezi University  Shihezi China"},{"name":"The NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, First Affiliated Hospital Shihezi University  Shihezi 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