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Multiple therapeutic proposals include, for example, anti\u2010inflammatory and immunosuppressive agents, selective inhibitors of key pro\u2010inflammatory receptors, and key enzymes necessary for viral replication. Unfortunately, safe and effective therapy remains an elusive goal. An alternative anti\u2010inflammatory approach vis \u00e1 vis omega\u20103 fatty acids, which yields less pro\u2010inflammatory mediators by altering eicosanoid metabolism, has been proposed. Although theoretically promising, enteral tube delivery or oral capsules containing specific doses of omega\u20103 fatty acids take precious time (7\u2009days to 6\u2009weeks) to be incorporated in plasma cell membranes to be most effective, making this route of administration in the acute care setting an unfeasible therapeutic approach. Parenteral administration of precise doses of omega\u20103 fatty acid triglycerides in an injectable emulsion can greatly accelerate the incorporation and potential therapeutic effects (within hours), but at present, there is no commercially available product designed for this purpose. We describe a potential formulation that may address this deficiency, while recognizing that the high incidence of hyperlipidemia that occurs during severe COVID\u201019 infection must be recognized as a complicating factor, and, therefore, caution is advised.<\/jats:p>","DOI":"10.1096\/fj.202300396r","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T10:19:17Z","timestamp":1688120357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytokine storm associated with severe\n                    <scp>COVID<\/scp>\n                    \u201019 infections: The potential mitigating role of omega\u20103 fatty acid triglycerides in the\n                    <scp>ICU<\/scp>"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-6748","authenticated-orcid":false,"given":"David F.","family":"Driscoll","sequence":"first","affiliation":[{"name":"Stable 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