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Activated macrophage is critical for directing the process of inflammation during the development of DCM. The present study focused on the roles of CD226 on macrophage function during the DCM progression. It has been found that the number of cardiac macrophages in the hearts of streptozocin (STZ)\u2010induced diabetes mice was significantly increased compared with that in non\u2010diabetes mice, and the expression level of CD226\u00a0on cardiac macrophages in STZ\u2010induced diabetes mice was higher than that in non\u2010diabetes mice. CD226 deficiency attenuated the diabetes\u2010induced cardiac dysfunction and decreased the proportion of CD86\n                    <jats:sup>+<\/jats:sup>\n                    F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    macrophages in the diabetic hearts. Notably, adoptive transfer of\n                    <jats:italic>Cd226<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    \u2010 bone marrow derived macrophages (BMDMs) alleviated diabetes\u2010induced cardiac dysfunction, which may be due to the attenuated migration capacity of\n                    <jats:italic>Cd226<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    \u2010BMDM under high glucose stimulation. Furthermore, CD226 deficiency decreased the macrophage glycolysis accompanying by the downregulated hexokinase 2 (HK2) and lactate dehydrogenase A (LDH\u2010A) expression. Taken together, these findings revealed the pathogenic roles of CD226 played in the process of DCM and provided a basis for the treatment of DCM.\n                  <\/jats:p>","DOI":"10.1096\/fj.202300424rr","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T11:40:36Z","timestamp":1688211636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in\n                    <scp>STZ<\/scp>\n                    \u2010induced diabetic mice"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-0418","authenticated-orcid":false,"given":"Yongli","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Immunology Fourth Military Medical University  Xi'an 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