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To delineate the reproductive function of\n                    <jats:italic>Mothers against decapentaplegic homolog 4<\/jats:italic>\n                    (\n                    <jats:italic>Smad4<\/jats:italic>\n                    ), we specifically inactivated\n                    <jats:italic>Smad4<\/jats:italic>\n                    in ovarian granulosa cells and, oviduct and uterine mesenchymal cells using the\n                    <jats:italic>Amhr2<\/jats:italic>\n                    \u2010\n                    <jats:italic>cre<\/jats:italic>\n                    mouse line. Deletion of\n                    <jats:italic>exon 8<\/jats:italic>\n                    of\n                    <jats:italic>Smad4<\/jats:italic>\n                    results in the production of an MH2\u2010truncated SMAD4 protein. These mutant mice are infertile due to the development of oviductal diverticula and defects during the implantation process. The ovaries are fully functional as demonstrated in an ovary transfer experiment. The development of oviductal diverticula occurs shortly after puberty and is dependent on estradiol. The diverticula interfere with sperm migration and embryo transit to the uterus, reducing the number of implantation sites. Analysis of the uterus shows that, even if implantation occurs, decidualization and vascularization are defective resulting in embryo resorption as early as the seventh day of pregnancy. Thus, Smad4 plays an important function in female reproduction by controlling the structural and functional integrity of the oviduct and uterus.\n                  <\/jats:p>","DOI":"10.1096\/fj.202300737r","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T11:10:37Z","timestamp":1688469037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uterine defects and estradiol\u2010dependent development of oviductal diverticula in mice lacking the\n                    <scp>SMAD4<\/scp>\n                    C\u2010terminal Mad homology 2 domain"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2077-6661","authenticated-orcid":false,"given":"Fabrice G.","family":"Petit","sequence":"first","affiliation":[{"name":"Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S1085  Rennes France"},{"name":"Univ Paris\u2010Sud, Inserm, UMR_S0782  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-3174","authenticated-orcid":false,"given":"Christine","family":"Kervarrec","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S1085  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-0270","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Allais\u2010Bonnet","sequence":"additional","affiliation":[{"name":"Univ Paris\u2010Sud, Inserm, UMR_S0782  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8525-2819","authenticated-orcid":false,"given":"Bertrand","family":"Evrard","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S1085  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-3628","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Chalmel","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S1085  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-3902","authenticated-orcid":false,"given":"Chuxia","family":"Deng","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Macau  Macau SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1688-0167","authenticated-orcid":false,"given":"Soazik P.","family":"Jamin","sequence":"additional","affiliation":[{"name":"Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) \u2013 UMR_S1085  Rennes France"},{"name":"Univ Paris\u2010Sud, Inserm, UMR_S0782  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001356"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep343"},{"key":"e_1_2_10_4_1","first-page":"1","article-title":"Recent advances in medically assisted conception. 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