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Molecular alterations involved in adult gliomas have been identified and mainly affect tyrosine kinase receptors with amplification and\/or mutation of the epidermal growth factor receptor (EGFR) and its associated signaling pathways. Several targeted therapies have been developed, but current treatments remain ineffective for glioblastomas, the most severe forms. Thus, it is a priority to identify new pharmacological targets.\n                    <jats:italic>Drosophila<\/jats:italic>\n                    glioma models established in larvae and adults are useful to identify new genes and signaling pathways involved in glioma progression. Here, we used a\n                    <jats:italic>Drosophila<\/jats:italic>\n                    glioma model in adults, to characterize metabolic disturbances associated with glioma and assess the consequences of 5\u2010HT\n                    <jats:sub>7<\/jats:sub>\n                    R expression on glioma development. First, by using in vivo magnetic resonance imaging, we have shown that expression of the constitutively active forms of EGFR and PI3K in adult glial cells induces brain enlargement. Then, we explored altered cellular metabolism by using high\u2010resolution magic angle spinning NMR and\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010\n                    <jats:sup>13<\/jats:sup>\n                    C heteronuclear single quantum coherence solution states. Discriminant metabolites identified highlight the rewiring of metabolic pathways in glioma and associated cachexia phenotypes. Finally, the expression of 5\u2010HT\n                    <jats:sub>7<\/jats:sub>\n                    R in this adult model attenuates phenotypes associated with glioma development. Collectively, this whole\u2010animal approach in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    allowed us to provide several rapid and robust phenotype readouts, such as enlarged brain volume and glioma\u2010associated cachexia, as well as to determine the metabolic pathways involved in glioma genesis and finally to confirm the interest of the 5\u2010HT\n                    <jats:sub>7<\/jats:sub>\n                    R in the treatment of glioma.\n                  <\/jats:p>","DOI":"10.1096\/fj.202300783rr","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:09:08Z","timestamp":1696230548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An adult\n                    <i>Drosophila<\/i>\n                    glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin\n                    <scp>\n                      5\u2010HT\n                      <sub>7<\/sub>\n                    <\/scp>\n                    receptor as a potential therapeutic target"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-5564","authenticated-orcid":false,"given":"Maryl\u00e8ne","family":"Bertrand","sequence":"first","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire\u2014CBM, UPR 4301, CNRS  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0219-0828","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Szeremeta","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire\u2014CBM, UPR 4301, CNRS  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-0944","authenticated-orcid":false,"given":"Nad\u00e8ge","family":"Hervouet\u2010Coste","sequence":"additional","affiliation":[{"name":"Centre 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