{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:59:42Z","timestamp":1774731582913,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K08140"],"award-info":[{"award-number":["17K08140"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K20452"],"award-info":[{"award-number":["19K20452"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obesity is a global health problem caused by genetic, environmental, and psychological factors and is associated with various health disorders. As such, there is a growing focus on the prevention of obesity and related diseases. The gut microbiota plays a crucial role in these diseases and has become a therapeutic target. Prebiotics, such as poly\u2010\n                    <jats:sc>d<\/jats:sc>\n                    \u20103\u2010hydroxybutyric acid (PHB), have gained attention for their potential to alter the gut microbiota, promote beneficial bacterial growth, and alleviate obesity. In this study, we examined the prebiotic effects of PHB in obese mice. We found that, in C57BL\/6N mice, PHB reduced blood lipid levels. Analysis of the intestinal microflora also revealed an increase in short\u2010chain fatty acid\u2010producing bacteria. When PHB was administered to obese mice, subcutaneous fat and dyslipidemia were reduced, and the number of beneficial bacteria in the intestinal microflora increased. Furthermore, fatty degradation and oxidative stress were suppressed in the liver. PHB regulates gut bacterial changes related to obesity and effectively inhibits dyslipidemia, suggesting that it could be a prebiotic agent for curing various obesity\u2010related diseases. In summary, PHB increases the beneficial gut microbiota, leading to an alleviation of obesity\u2010associated dyslipidemia.\n                  <\/jats:p>","DOI":"10.1096\/fj.202301191r","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T06:44:53Z","timestamp":1691390693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prebiotic effect of\n                    <scp>poly\u2010D<\/scp>\n                    \u20103\u2010hydroxybutyrate prevents dyslipidemia in obese mice"],"prefix":"10.1096","volume":"37","author":[{"given":"Mayuko","family":"Mishima","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-7656","authenticated-orcid":false,"given":"Masaki","family":"Nagane","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"},{"name":"Center for Human and Animal Symbiosis Science Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Ogata","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Shima","sequence":"additional","affiliation":[{"name":"Anicom Specialty Medical Institute Inc.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Aihara","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kamiie","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimina","family":"Suzuki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinano","family":"Mizugaki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-9080","authenticated-orcid":false,"given":"Yuko","family":"Okamatsu\u2010Ogura","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Antiaging Food Research, School of Bioscience and Biotechnology Tokyo University of Technology  Hachioji Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8022-0158","authenticated-orcid":false,"given":"Tadashi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Azabu University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35007508"},{"key":"e_1_2_10_3_1","volume-title":"Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation","author":"WHO","year":"2000"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000216787.85457.f3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.16.1530"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00032.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0420-z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.22.011602.092259"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104816"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809302"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223813"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i25.3837"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209788168164"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520000380"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05414"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/chi.2018.0040"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00440-6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116097"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00260"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/693253"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.54.4.450-472.1990"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200919R"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.26502\/jbb.2642-91280056"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-017-7273-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.05.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-022-2213-6"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.112"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnz095"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100721RR"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.104"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.757718"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180448"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0372"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199604000-00014"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1066-1"},{"issue":"1","key":"e_1_2_10_39_1","first-page":"S51","article-title":"Therapy of NAFLD: antioxidants and cytoprotective agents","volume":"40","author":"Chang CY","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.06.015"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00346.2017"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800446"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76474-8"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0433-9"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31353-1"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202301191R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:45:08Z","timestamp":1761684308000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202301191R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1096\/fj.202301191R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202301191r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,7]]},"assertion":[{"value":"2023-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23121"}}