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Cell senescence is a common phenotype in many diseases; however, few studies have reported whether it occurs in photoreceptor degeneration diseases. Herein, we identified that cell senescence is associated with photoreceptor degeneration induced by N\u2010methyl\u2010N\u2010nitrosourea (MNU, a commonly used photoreceptor degeneration model), presented as increased senescence\u2010associated \u03b2\u2010galactosidase activity, DNA damage, oxidative stress and inflammation\u2010related cytokine Interleukin 6 (IL6), and upregulation of cyclin p21 or p16. These results suggested that visual function might be protected using anti\u2010aging treatment. Furthermore, Hyperoside is reported to help prevent aging in various organs. In this study, we showed that Hyperoside, delivered intravitreally,\u00a0alleviated photoreceptor cell senescence and ameliorated the functional and morphological degeneration of the retina in vivo and in vitro. Importantly, Hyperoside attenuated the MNU\u2010induced injury and aging of photoreceptors via AMPK\u2010ULK1 signaling inhibition. Taken together, our results demonstrated that Hyperoside can prevent MNU\u2010induced photoreceptor degeneration by inhibiting cell senescence via the AMPK\u2010ULK1 pathway.<\/jats:p>","DOI":"10.1096\/fj.202301273rr","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:51:41Z","timestamp":1697075501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hyperoside alleviates photoreceptor degeneration by preventing cell senescence through\n                    <scp>AMPK\u2010ULK1<\/scp>\n                    signaling"],"prefix":"10.1096","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-6442","authenticated-orcid":false,"given":"Jia","family":"Liang","sequence":"first","affiliation":[{"name":"Shenzhen Eye Hospital Shenzhen Eye Institute, Jinan University  Shenzhen Guangdong 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