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Our previous study revealed that the A\u03b2 expression level is closely related to ARC progression. Here, we demonstrated that the accumulation of A\u03b2Os in the lens epithelium of age\u2010related cataract (ARC) patients increased during ARC progression and that this alteration was consistent with the changes in mitochondrial function, oxidative stress, and cellular apoptosis. In\u00a0vitro, human lens epithelial cells (HLECs) treated with A\u03b2Os exhibited Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dyshomeostasis, impaired mitochondrial function, elevated oxidative stress levels, and increased apoptosis. Moreover, the proapoptotic effect of A\u03b2Os was alleviated after the uptake of mitochondrial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    was inhibited. These results establish that A\u03b2Os may promote HLEC apoptosis by inducing mitochondrial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    overload, thus preliminarily revealing the possible association between the accumulation of A\u03b2Os and other pathological processes in ARC.\n                  <\/jats:p>","DOI":"10.1096\/fj.202301281rr","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T05:07:31Z","timestamp":1725858451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated concentrations of amyloid\u2010\u03b2 oligomers and their proapoptotic effects on age\u2010related cataract"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-4576","authenticated-orcid":false,"given":"Peimin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye &amp; ENT Hospital Fudan University  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