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However, the presence of HEV in the female genital tract is unreported. Vaginal secretions, cervical smears, and cervix uteri were collected to explore the presence of HEV in the female genital tract. HEV RNA and\/or antigens were detected in the vaginal secretions, cervical smears, and the cervix uteri of women. The infectivity of HEV excreted into vaginal secretions was further validated\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    . In addition, HEV replicates in the female genital tract were identified in HEV\u2010infected animal models by vaginal injection or vaginal mucosal infection to imitate sexual transmission. Serious genital tract damage and inflammatory responses with significantly elevated mucosal innate immunity were observed in women or animals with HEV vaginal infection. Results demonstrated HEV replicates in the female genital tract and causes serious histopathological damage and inflammatory responses.\n                  <\/jats:p>","DOI":"10.1096\/fj.202301519rr","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:20:24Z","timestamp":1709637624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Infectious hepatitis E virus excreted into the vagina"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-8101","authenticated-orcid":false,"given":"Chao","family":"Cong","sequence":"first","affiliation":[{"name":"School of Medicine, The Academy for Cells and Life Health, Faculty of Life Science and Technology Kunming University of Science and Technology  Kunming PR 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