{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:53:12Z","timestamp":1793649192978,"version":"4.5.1"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["22T001"],"award-info":[{"award-number":["22T001"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Postprandial hyperglycemia is an early indicator of impaired glucose tolerance that leads to type 2 diabetes mellitus (T2DM). Alterations in the fatty acid composition of phospholipids have been implicated in diseases such as T2DM and nonalcoholic fatty liver disease. Lysophospholipid acyltransferase 10 (LPLAT10, also called LPCAT4 and LPEAT2) plays a role in remodeling fatty acyl chains of phospholipids; however, its relationship with metabolic diseases has not been fully elucidated. LPLAT10 expression is low in the liver, the main organ that regulates metabolism, under normal conditions. Here, we investigated whether overexpression of LPLAT10 in the liver leads to improved glucose metabolism. For overexpression, we generated an LPLAT10\u2010expressing adenovirus (Ad) vector (Ad\u2010LPLAT10) using an improved Ad vector. Postprandial hyperglycemia was suppressed by the induction of glucose\u2010stimulated insulin secretion in Ad\u2010LPLAT10\u2010treated mice compared with that in control Ad vector\u2010treated mice. Hepatic and serum levels of phosphatidylcholine 40:7, containing C18:1 and C22:6, were increased in Ad\u2010LPLAT10\u2010treated mice. Serum from Ad\u2010LPLAT10\u2010treated mice showed increased glucose\u2010stimulated insulin secretion in mouse insulinoma MIN6 cells. These results indicate that changes in hepatic phosphatidylcholine species due to liver\u2010specific LPLAT10 overexpression affect the pancreas and increase glucose\u2010stimulated insulin secretion. Our findings highlight LPLAT10 as a potential novel therapeutic target for T2DM.<\/jats:p>","DOI":"10.1096\/fj.202301594rr","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T09:29:22Z","timestamp":1705397362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Overexpression of lysophospholipid acyltransferase,\n                    <scp>LPLAT10<\/scp>\n                    \/\n                    <scp>LPCAT4<\/scp>\n                    \/\n                    <scp>LPEAT2<\/scp>\n                    , in the mouse liver increases glucose\u2010stimulated insulin secretion"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-5526","authenticated-orcid":false,"given":"Kahori","family":"Shimizu","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Ono","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenari","family":"Mikamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Urayama","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Hase","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Michinaga","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics Meiji Pharmaceutical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Lipidome Lab Co., Ltd  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Terada","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences Osaka University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-8178","authenticated-orcid":false,"given":"Hiroyuki","family":"Mizuguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences Osaka University  Osaka Japan"},{"name":"Global Center for Medical Engineering and Informatics Osaka University  Osaka Japan"},{"name":"Laboratory of Functional Organoid for Drug Discovery National Institutes of Biomedical Innovation, Health and Nutrition  Osaka Japan"},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives Osaka University  Osaka Japan"},{"name":"Center for Infectious Disease Education and Research (CiDER) Osaka University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-913X","authenticated-orcid":false,"given":"Hideo","family":"Shindou","sequence":"additional","affiliation":[{"name":"Department of Lipid Life Science National Center for Global Health and Medicine  Tokyo Japan"},{"name":"Department of Medical Lipid Science, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tomita","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nishinaka","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy Osaka Ohtani University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.151"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.s117"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.198"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.02.001"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1277"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0054"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23962"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70453-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.08.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800046200"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101470"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320646"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06557"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06328"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301122RR"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700184-JLR200"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R066357"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M014787"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21763"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600225200"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800500-JLR200"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609641200"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601183R"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.03.074"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800364200"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12221"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M031773"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114444"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0892-372"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtm.2014.35"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000830"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.17-2577"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950017374"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1400-2656"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(68)90121-9"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1987.9999"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274297"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.790568"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208396"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0094-z"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0726"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.02.001"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154892"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.334664"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102658"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11002-4"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.05.019"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-162818"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.791277"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.034355"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.s53"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.628420"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0581"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01478"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo01942a"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.01.009"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52048-1"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.03.076"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4350"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.2337\/db20-1079"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0055"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.1.8319569"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25428-3"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202301594RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:36:53Z","timestamp":1761694613000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202301594RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,31]]}},"alternative-id":["10.1096\/fj.202301594RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202301594rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]},"assertion":[{"value":"2023-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23425"}}