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However, whether a dominant bacteria can promote the progression of pulpitis and its underlying mechanism remains unclear. We provided a comprehensive assessment of the microbiota alteration in pulpitis using 16S rRNA sequencing.\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    was the most enriched in pulpitis and played a pathogenic role accelerating pulpitis progression in rat pulpitis model. After odontoblast\u2010like cells cocultured with\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    , the stimulator of interferon genes (STING) pathway and autophagy were activation. There was a float of STING expression during\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    stimulation. STING was degraded by autophagy at the early stage. At the late stage,\n                    <jats:italic>F.\u00a0nucleatum<\/jats:italic>\n                    stimulated mitochondrial Reactive Oxygen Species (ROS) production, mitochondrial dysfunction and then mtDNA escape into cytosol. mtDNA, which escaped into cytosol, caused more cytosolic mtDNA binds to cyclic GMP\u2010AMP synthase (cGAS). The release of IFN\u2010\u03b2 was dramatically reduced when mtDNA\u2010cGAS\u2010STING pathway inhibited. STING\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed milder periapical bone loss and lower serum IFN\u2010\u03b2 levels compared with wildtype mice after 28\u2009days\u2009\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    \u2010infected pulpitis model establishment. Our data demonstrated that\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    exacerbated the progression of pulpitis, which was mediated by the STING\u2010dependent pathway.\n                  <\/jats:p>","DOI":"10.1096\/fj.202301648r","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T19:35:18Z","timestamp":1702409718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Fusobacterium nucleatum<\/i>\n                    exacerbates the progression of pulpitis by regulating the\n                    <scp>STING<\/scp>\n                    \u2010dependent pathway"],"prefix":"10.1096","volume":"38","author":[{"given":"Lu","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology School &amp; Hospital of Stomatology, Wuhan University  Wuhan China"},{"name":"Department of Cariology and Endodontics, School and Hospital of Stomatology Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Qing","family":"Mao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology School &amp; Hospital of Stomatology, Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Qi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology School &amp; Hospital of Stomatology, Wuhan University  Wuhan 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