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Here, we investigated the impact of maternal ZIKV infection on placental nutrient transporters and nutrient\u2010sensitive pathways. Immunocompetent (C57BL\/6) mice were injected with Low (10\n                    <jats:sup>3<\/jats:sup>\n                    PFU\u2010ZIKV\n                    <jats:sub>PE243<\/jats:sub>\n                    ) or High (5\u2009\u00d7\u200910\n                    <jats:sup>7<\/jats:sup>\n                    PFU\u2010ZIKV\n                    <jats:sub>PE243<\/jats:sub>\n                    ) ZIKV titers at gestational day (GD) 12.5, and tissue was collected at GD18.5 (term). Fetal\u2013placental growth was impaired in male fetuses, which exhibited higher placental expression of the ZIKV infective marker, eukaryotic translation initiation factor 2 (eIF2\u03b1), but lower levels of phospho\u2010eIF2\u03b1. There were no differences in fetal\u2013placental growth in female fetuses, which exhibited no significant alterations in placental ZIKV infective markers. Furthermore, ZIKV promoted increased expression of glucose transporter type 1 (\n                    <jats:italic>Slc2a1<\/jats:italic>\n                    \/Glut1) and decreased levels of glucose\u20106\u2010phosphate in female placentae, with no differences in amino acid transport potential. In contrast, ZIKV did not impact glucose transporters in male placentae but downregulated sodium\u2010coupled neutral amino acid 2 (Snat2) transporter expression. We also observed sex\u2010dependent differences in the hexosamine biosynthesis pathway (HBP) and O\u2010GlcNAcylation in ZIKV\u2010infected pregnancies, showing that ZIKV can disturb placental nutrient sensing. Our findings highlight molecular alterations in the placenta caused by maternal ZIKV infection, shedding light on nutrient transport, sensing, and availability. Our results also suggest that female and male placentae employ distinct coping mechanisms in response to ZIKV\u2010induced metabolic changes, providing insights into therapeutic approaches for congenital Zika syndrome.\n                  <\/jats:p>","DOI":"10.1096\/fj.202301951rr","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T08:20:02Z","timestamp":1720513202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex\u2010specific effect of antenatal Zika virus infection on murine fetal growth, placental nutrient transporters, and nutrient sensor signaling pathways"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-899X","authenticated-orcid":false,"given":"Daniela","family":"Pereira\u2010Carvalho","sequence":"first","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro  Rio de 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