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In this study, we identified a new active peptide (advanced glycation end products receptors RAGE\n                    <jats:sub>344\u2010355<\/jats:sub>\n                    ) from PCOS follicular fluid using mass spectrometry. We found that supplementing PCOS\u2010like mouse oocytes with RAGE\n                    <jats:sub>344\u2010355<\/jats:sub>\n                    attenuated both meiotic defects and oxidative stress levels, ultimately preventing developmental defects. Additionally, our results suggest that RAGE\n                    <jats:sub>344\u2010355<\/jats:sub>\n                    may interact with eEF1a1 to mitigate oxidative meiotic defects in PCOS\u2010like mouse oocytes. These findings highlight the potential for further clinical development of RAGE\n                    <jats:sub>344\u2010355<\/jats:sub>\n                    as a potent supplement and therapeutic option for women with PCOS. This research addresses an important clinical problem and offers promising opportunities for improving oocyte quality in PCOS patients.\n                  <\/jats:p>","DOI":"10.1096\/fj.202302038rr","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T11:05:00Z","timestamp":1710241500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peptide derived from\n                    <scp>RAGE<\/scp>\n                    efficiently improves oocyte development through attenuating oxidative stress in oocytes of mice with polycystic ovary syndrome"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1044-3617","authenticated-orcid":false,"given":"Xiaojing","family":"Hou","sequence":"first","affiliation":[{"name":"Nanjing Women and Children's HealthCare Hospital Women's Hospital of Nanjing Medical University  Nanjing 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