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As a new type of non\u2010coding RNA, circRNA has been shown to play a crucial role in the development of FGR. This investigation identified the downregulation of hsa_circ_0034533 (circTHBS1) in FGR placentas through high\u2010sequencing analysis and confirmed this finding in 25 clinical placenta samples using qRT\u2010PCR. Subsequent in\u00a0vitro functional assays demonstrated that silencing circTHBS1 inhibited trophoblast proliferation, migration, invasion, and epithelial mesenchymal transition (EMT) progression and promoted apoptosis. Furthermore, when circTHBS1 was overexpressed, cell function experiments showed the opposite result. Analysis using fluorescence in\u00a0situ hybridization revealed that circTHBS1 was primarily found in the cytoplasmic region. Through bioinformatics analysis, we anticipated the involvement of miR\u2010136\u20103p and IGF2R in downstream processes, which was subsequently validated through qRT\u2010PCR and dual\u2010luciferase assays. Moreover, the inhibition of miR\u2010136\u20103p or the overexpression of IGF2R partially reinstated proliferation, migration, and invasion abilities following the silencing of circTHBS1. In summary, the circTHBS1\/miR\u2010136\u20103p\/IGF2R axis plays a crucial role in the progression and development of FGR, offering potential avenues for the exploration of biological indicators and treatment targets.<\/jats:p>","DOI":"10.1096\/fj.202302113rr","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T04:55:26Z","timestamp":1712379326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>CircTHBS1<\/scp>\n                    promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating\n                    <scp>miR\u2010136\u20103p\/IGF2R<\/scp>\n                    axis"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-677X","authenticated-orcid":false,"given":"Yanyan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis, Zhujiang 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