{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T10:49:33Z","timestamp":1794134973184,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110645"],"award-info":[{"award-number":["2022A1515110645"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,2,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The prevalence of alopecia has increased recently. Hair loss is often accompanied by the resting phase of hair follicles (HFs). Dermal papilla (DP) plays a crucial role in HF development, growth, and regeneration. Activating DP can revive resting HFs. Augmenting WNT\/\u03b2\u2010catenin signaling stimulates HF growth. However, the factors responsible for activating resting HFs effectively are unclear. In this study, we investigated epidermal cytokines that can activate resting HFs effectively. We overexpressed \u03b2\u2010catenin in both in\u00a0vivo and in\u00a0vitro models to observe its effects on resting HFs. Then, we screened potential epidermal cytokines from GEO DATASETs and assessed their functions using mice models and skin\u2010derived precursors (SKPs). Finally, we explored the molecular mechanism underlying the action of the identified cytokine. The results showed that activation of WNT\/\u03b2\u2010catenin in the epidermis prompted telogen\u2013anagen transition. Keratinocytes infected with Ctnnb1\u2010overexpressing lentivirus enhanced SKP expansion. Subsequently, we identified endothelin 1 (ET\u20101) expressed higher in hair\u2010growing epidermis and induced the proliferation of DP cells and activates telogen\u2010phase HFs in\u00a0vivo. Moreover, ET\u20101 promotes the proliferation and stemness of SKPs. Western blot analysis and in\u00a0vivo experiments revealed that ET\u20101 induces the transition from telogen\u2010to\u2010anagen phase by upregulating the PI3K\/AKT pathway. These findings highlight the potential of ET\u20101 as a promising cytokine for HF activation and the treatment of hair loss.<\/jats:p>","DOI":"10.1096\/fj.202302207r","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T08:59:56Z","timestamp":1707469196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Epidermal\n                    <scp>ET<\/scp>\n                    \u20101 signal induces activation of resting hair follicles by upregulating the\n                    <scp>PI3K<\/scp>\n                    \/\n                    <scp>AKT<\/scp>\n                    pathway in the dermis"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7809-7238","authenticated-orcid":false,"given":"Ying","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Bengbu Medical University  Bengbu China"},{"name":"Department of Anesthesiology The First People's Hospital of Foshan  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6192-7874","authenticated-orcid":false,"given":"Zhimeng","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Life Sciences Tsinghua University  Beijing China"},{"name":"Faculty of Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-0677","authenticated-orcid":false,"given":"Xing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-7182","authenticated-orcid":false,"given":"Deqiang","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Life Sciences Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-6692","authenticated-orcid":false,"given":"Jimin","family":"Han","sequence":"additional","affiliation":[{"name":"School of Life Sciences Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-8136","authenticated-orcid":false,"given":"Weiwei","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Bengbu Medical University  Bengbu 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