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However, studies on the role of CD in immune cell development and differentiation, as well as the rhythmic expression of the core clock genes and their altered expression under CD, remain unclear. Therefore, we exposed C57bl\/6j mice to repeated reversed light\u2013dark cycles for 90\u2009days to research the effects of CD on bone marrow (BM) hematopoietic function. We also researched the effects of CD on endogenous circadian rhythms, temporally dependent expression in peripheral blood and myeloid leukocytes, environmental homeostasis within BM, and circadian oscillations of hematopoietic\u2013extrinsic cues. Our results confirmed that when the light and dark cycles around mice were frequently reversed, the circadian rhythmic expression of the two main circadian rhythm markers, the hypothalamic clock gene, and serum melatonin, was disturbed, indicating that the body was in a state of endogenous CD. Furthermore, CD altered the temporally dependent expression of peripheral blood and BM leukocytes and destroyed environmental homeostasis within the BM as well as circadian oscillations of hematopoietic\u2013extrinsic cues, which may negatively affect BM hematopoiesis in mice. Collectively, these results demonstrate that circadian rhythms are vital for maintaining health and suggest that the association between CD and hematopoietic dysfunction warrants further investigation.<\/jats:p>","DOI":"10.1096\/fj.202302233rr","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T10:19:05Z","timestamp":1711966745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circadian disturbances by altering the light\u2013dark cycle negatively affects hematopoietic function of bone marrow in mice"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2874-9852","authenticated-orcid":false,"given":"Honglian","family":"Yang","sequence":"first","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin 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