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Following an articular cartilage injury, an inability to resist vascular invasion can result in cartilage calcification by newly formed blood vessels. This process ultimately leads to the loss of joint function, significantly impacting the patient's quality of life. As a result, developing anti\u2010angiogenic methods to repair damaged cartilage has become a popular research topic. Despite this, tissue engineering, as an anti\u2010angiogenic strategy in cartilage injury repair, has not yet been adequately investigated. This exhaustive literature review mainly focused on the process and mechanism of vascular invasion in articular cartilage injury repair and summarized the major regulatory factors and signaling pathways affecting angiogenesis in the process of cartilage injury. We aimed to discuss several potential methods for engineering cartilage repair with anti\u2010angiogenic strategies. Three anti\u2010angiogenic tissue engineering methods were identified, including administering angiogenesis inhibitors, applying scaffolds to manage angiogenesis, and utilizing in\u00a0vitro bioreactors to enhance the therapeutic properties of cultured chondrocytes. The advantages and disadvantages of each strategy were also analyzed. By exploring these anti\u2010angiogenic tissue engineering methods, we hope to provide guidance for researchers in related fields for future research and development in cartilage repair.<\/jats:p>","DOI":"10.1096\/fj.202302391rr","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T10:27:15Z","timestamp":1710844035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mechanisms of vascular invasion after cartilage injury and potential engineering cartilage treatment strategies"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0022-5094","authenticated-orcid":false,"given":"Zitong","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Integrated Chinese and Western Medicine Nanjing University of Chinese Medicine  Nanjing P.R. 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