{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:40:54Z","timestamp":1780490454066,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["XYFY2021017"],"award-info":[{"award-number":["XYFY2021017"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CircRNAs are abnormally expressed in various cancers and play an important role in the occurrence and development of cancers. However, their biological functions and the underlying molecular mechanisms in pancreatic cancer (PC) metastasis are incompletely understood. Differentially expressed circRNAs were identified by second\u2010generation transcriptome sequencing in three pairs of PC tissues and adjacent tissues. The expression and prognostic significance of hsa_circ_0007919 were evaluated by qRT\u2010PCR and Kaplan\u2013Meier survival curves. Gain\u2010 and loss\u2010of\u2010function assays were conducted to detect the role of hsa_circ_0007919 in PC metastasis in\u00a0vitro. A lung metastasis model and IHC experiments were conducted to confirm the effects of hsa_circ_0007919 on tumor metastasis in\u00a0vivo. Mechanistically, RNA immunoprecipitation and chromatin immunoprecipitation assays were conducted to explore the interplay among hsa_circ_0007919, Sp1, and the THBS1 promoter. hsa_circ_0007919 was significantly upregulated in PC tissues and cells and was correlated with lymph node metastasis, TNM stage, and poor prognosis. Knockdown of hsa_circ_0007919 significantly suppressed the migration and invasion of PC cells in\u00a0vitro and inhibited tumor metastasis in\u00a0vivo. However, overexpression of hsa_circ_0007919 exerted the opposite effects. Mechanistically, hsa_circ_0007919 could recruit the transcription factor Sp1 to inhibit THBS1 transcription, thereby facilitating PC metastasis. hsa_circ_0007919 can promote the metastasis of PC by inhibiting THBS1 expression. hsa_circ_0007919 may be a potential therapeutic target in PC.<\/jats:p>","DOI":"10.1096\/fj.202302422rr","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T04:16:14Z","timestamp":1712204174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1\u2010mediated\n                    <scp>THBS1<\/scp>\n                    transcription"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9200-3197","authenticated-orcid":false,"given":"Xiao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Institute of Digestive Diseases Xuzhou Medical University  Xuzhou China"},{"name":"Department of General Surgery Xuzhou First People's Hospital  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Institute of Digestive Diseases Xuzhou Medical University  Xuzhou China"},{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Institute of Digestive Diseases Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Institute of Digestive Diseases Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Institute of Digestive Diseases Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Institute of Digestive Diseases Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"},{"name":"Institute of Digestive Diseases Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13027"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62307-0"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.36290\/vnl.2022.076"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09719-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0359"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.v18.i1-2.40"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0134-x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0321-5"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108647"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00544-0"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249739"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01180-y"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0663-2"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2018.12.002"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00585-y"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01599-5"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05188-8"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094570"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2561"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713312"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119236"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065164"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01286-3"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00948-7"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01383-x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.08.027"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01585-7"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7484-1"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7486-z"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009712"},{"key":"e_1_2_13_33_1","first-page":"291","article-title":"THBS1 (thrombospondin\u20101)","volume":"24","author":"Isenberg JS","year":"2020","journal-title":"Atlas Genet Cytogenet Oncol Haematol"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.376"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02308-8"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0578-03"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-018-9644-3"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003834200"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2009.09.002"},{"key":"e_1_2_13_40_1","first-page":"1189","article-title":"Thrombospondin\u20101 expression as a prognostic predictor of pancreatic ductal carcinoma","volume":"21","author":"Tobita K","year":"2002","journal-title":"Int J Oncol"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-2-206"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13148"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42501-6"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01096-7"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.936037"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1947939"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-020-00510-4"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2062196"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.01.063"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00282.2011"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202302422RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:47:12Z","timestamp":1761684432000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202302422RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,4]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4,15]]}},"alternative-id":["10.1096\/fj.202302422RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202302422rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,4]]},"assertion":[{"value":"2023-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23591"}}