{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:09:02Z","timestamp":1790759342084,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Retinitis pigmentosa GTPase regulator interacting protein 1\u2010like (\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    ) gene encodes an important protein that performs various physiological functions. Variants of\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    are related to a number of diseases. However, it is currently unknown whether\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    is correlated with breast invasive carcinoma (BRCA). In BRCA tissue specimens, the expression of\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    was found to be elevated in comparison to its levels in normal breast tissue. A notable decline in survival rates was associated with patients exhibiting heightened\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    gene expression. Consistent with these findings, our data also show the above results. Furthermore, elevated expression of\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    corresponded with a spectrum of unfavorable clinicopathological features, including the presence of human epidermal growth factor receptor 2 (HER2) positive, estrogen receptor (ER) positive, over 60\u2009years old, T2, N0, and N3. At the same time, our research indicated that 50 genes and 15 proteins were positively related to\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    , and that these proteins and genes were mostly involved in T cell proliferation, immune response, cytokine activity, and metabolic regulation. In addition, in the present study, there was a significant correlation between\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    expression and immune cell infiltration. Finally, we found that four Chemicals could downregulate the expression of\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    . Altogether, our results strongly indicated that\n                    <jats:italic>RPGRIP1L<\/jats:italic>\n                    might serve as a new prognostic biomarker for BRCA.\n                  <\/jats:p>","DOI":"10.1096\/fj.202302523r","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T04:02:13Z","timestamp":1715745733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>\n                      <i>RPGRIP1L<\/i>\n                    <\/scp>\n                    as a new biomarker for prognosis and tumor immune of breast cancer"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-3285","authenticated-orcid":false,"given":"Jianing","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Gland Surgery, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha 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