{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:02:36Z","timestamp":1789585356876,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,2,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Type 2 helper cells (Th2 cells) differentiate from CD4 helper T cells under the influence of IL\u20104 and conventional or monocyte\u2010derived CD11b\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells. Th2 cells are capable of generating IL\u20104, IL\u20105, and IL\u201013, as well as evoking immunoglobulin class\u2010switch to IgE. Three types of rapid immune responses are Th2 cell\u2010dependent: (1) mast cell\u2010IgE mediated allergic reactions, (2) Th2 cell\u2010derived cytokine\u2010mediated reactions that complement allergic reactions and protect the host from toxins, xenobiotics, environmental irritants, and helminthic parasites, and (3) IgE\u2010stimulated mast cell\u2010derived cysteinyl\u2010leukotriene mediated avoidance of toxins. The contributions of Th2 cell\u2010derived cytokines to eosinophilia (IL\u20105), IgE class\u2010switch, and epithelial barrier activation, mucous secretion, and metaplasia (IL\u20104 and IL\u201013) in asthma, allergic rhinitis with polyps and atopic dermatitis have led to anti\u2010cytokine monoclonal antibody treatments. Anti\u2010IL\u20105 neutralizing monoclonal antibody in asthma and anti\u2010IL\u20104\/IL\u201013 receptor neutralizing monoclonal antibody in asthma and atopic dermatitis are proven successful therapies in appropriately selected patients who are not sufficiently improved by conventional treatments.\n                  <\/jats:p>","DOI":"10.1096\/fj.202302584rr","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T11:09:55Z","timestamp":1708340995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Th2 cells in rapid immune responses and protective avoidance reactions"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-5371","authenticated-orcid":false,"given":"Edward J.","family":"Goetzl","sequence":"first","affiliation":[{"name":"Research Department, Geriatric Research Center University of California Medical Center, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1357"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.118"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12387"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11047"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S275039"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00737-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjresp-2022-001341","article-title":"Clinical utility of anti\u2010interleukin 5 monoclonal therapy in asthma using a national, centralised, outcome\u2010based system of drug access","volume":"9","author":"O'Leary C","year":"2022","journal-title":"BMJ Open Respir Res"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.851940"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336525"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25511"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06362-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06188-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb00655.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12596"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.81868"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70263-6"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202302584RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:54:41Z","timestamp":1761699281000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202302584RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2,29]]}},"alternative-id":["10.1096\/fj.202302584RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202302584rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"2023-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23485"}}