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Incubation of NDV with the malaria parasites dose\u2010dependently reduces its cellular viability. The antiplasmodial activity of NDV is specific, as incubation with Japanese encephalitis virus, duck enteritis virus, infectious bronchitis virus, and influenza virus did not affect the parasite propagation. Interestingly, NDV is reducing more than 80% invasion when RBCs are pretreated with the virus. Removal of the RBC surface proteins or the NDV coat proteins results in disruption of the virus binding to RBC. It suggests the involvement of specific protein: ligand interaction in virus binding. We established that the virus engages with the parasitized RBCs (PRBCs) through its hemagglutinin neuraminidase (HN) protein by recognizing sialic acid\u2010containing glycoproteins on the cell surface. Blocking of the HN protein with free sialic acid or anti\u2010HN antibodies abolished the virus binding as well as its ability to reduce parasite growth. Interestingly, the purified HN from the virus alone could inhibit the parasite's growth in a dose\u2010dependent manner. NDV binds strongly to knobless murine parasite strain\n                    <jats:italic>Plasmodium yoelii<\/jats:italic>\n                    and restricted the parasite growth in mice. Furthermore, the virus was found to preferentially target the PRBCs compared to normal erythrocytes. Immunolocalization studies reveal that NDV is localized on the plasma membrane as well as weakly inside the PRBC. NDV causes neither any infection nor aggregation of the human RBCs. Our findings suggest that NDV is a potential candidate for developing targeted drug delivery platforms for the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2010infected RBCs.\n                  <\/jats:p>","DOI":"10.1096\/fj.202400004rr","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T08:55:07Z","timestamp":1722588907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>NDV<\/scp>\n                    targets the invasion pathway in malaria parasite through cell surface sialic acid interaction"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6865-0299","authenticated-orcid":false,"given":"Siddharth","family":"Neog","sequence":"first","affiliation":[{"name":"Malaria Research Group, Department of Biosciences and Bioengineering Indian Institute of Technology\u2010Guwahati  Guwahati India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2995-7218","authenticated-orcid":false,"given":"Sandeep Reddy","family":"Vinjamuri","sequence":"additional","affiliation":[{"name":"School of Biology Indian Institute of Science Education and Research Thiruvananthapuram  Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-7780","authenticated-orcid":false,"given":"Kamalakannan","family":"Vijayan","sequence":"additional","affiliation":[{"name":"School of Biology Indian Institute of Science Education and Research Thiruvananthapuram  Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8526-6013","authenticated-orcid":false,"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Viral Immunology Laboratory, Department of Biosciences and Bioengineering Indian Institute of Technology\u2010Guwahati  Guwahati India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-6083","authenticated-orcid":false,"given":"Vishal","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Malaria Research Group, Department of Biosciences and Bioengineering Indian Institute of Technology\u2010Guwahati  Guwahati India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0911-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2019.01.029"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106057"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109767"},{"issue":"4","key":"e_1_2_11_6_1","first-page":"179","article-title":"Acute psychosis after mefloquine. 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