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Tibial involvement leads to bowing and predisposes to the development of a fracture which exhibit significantly delayed healing processes, leading to prolonged morbidity. We previously identified gain\u2010of\u2010function mutations in the MET gene as a cause for OFD. In our present study, we test the hypothesis that gain\u2010of\u2010function MET mutations impair bone repair due to reduced osteoblast differentiation. A heterozygous\n                    <jats:italic>Met<\/jats:italic>\n                    exon 15 skipping\n                    <jats:italic>(Met<\/jats:italic>\n                    <jats:sup>\u039415<\/jats:sup>\n                    \u2010HET) mouse was created to imitate the human OFD mutation. The mutation results in aberrant and dysregulation of MET\u2010related signaling determined by RNA\u2010seq in the murine osteoblasts extracted from the wide\u2010type and genetic mice. Although no gross skeletal defects were identified in the mice, fracture repair was delayed in\n                    <jats:italic>Met<\/jats:italic>\n                    <jats:sup>\u039415<\/jats:sup>\n                    \u2010HET mice, with decreased bone formation observed 2\u2010week postfracture. Our data are consistent with a novel role for MET\u2010mediated signaling regulating osteogenesis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202400075rr","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T11:29:02Z","timestamp":1721734142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A genetic mouse model mimicking MET related human osteofibrous dysplasia is characterized by delays in fracture repair and defective osteogenesis"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-5565","authenticated-orcid":false,"given":"Guoju","family":"Hong","sequence":"first","affiliation":[{"name":"Traumatology &amp; Orthopedics Institute, Guangzhou University of Chinese Medicine  Guangzhou Guangdong P.R. 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