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FABP5 expression was significantly upregulated in the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyl\u2010\n                    <jats:sc>d<\/jats:sc>\n                    \u2010aspartic acid (NMDA) model, the microbead\u2010induced chronic glaucoma model, and the DBA\/2J mice. Previous studies have demonstrated that FABP5 can mediate mitochondrial dysfunction and oxidative stress in ischemic neurons, but the role of FABP5 in oxidative stress and cell death in retina NMDA injury models is unclear. In this study, we found that FABP5 is significantly altered in a model of glutamate excitotoxicity and is regulated by Stat3. Inhibition of FABP5 alleviated oxidative stress imbalance and activation of NLRP3 inflammasome, reduced the release of inflammatory factors, and ultimately attenuated glutamate excitotoxicity\u2010induced retinal ganglion cell loss. Meanwhile, caspase1 inhibitors could alleviate the retinal ganglion cell loss induced by glutamate excitotoxicity. In conclusion, FABP5 inhibition protects retina ganglion cells from excitotoxic damage by suppressing the ROS\u2010NLRP3 inflammasome pathway. FABP5 maybe a promising new target for glaucoma diagnosis and treatment.\n                  <\/jats:p>","DOI":"10.1096\/fj.202400435r","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T11:04:10Z","timestamp":1736507050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["FABP5 regulates ROS\u2010NLRP3 inflammasome in glutamate\u2010induced retinal excitotoxic glaucomatous model"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8977-1694","authenticated-orcid":false,"given":"Zhou","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Eye Center Xiangya Hospital, Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Ophthalmology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  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