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Here, we investigated the expression and functions of poly(ADP\u2010ribose) polymerase 14 (Parp14), an important regulatory protein in immune cells, with an IBD patient cohort as well as two mouse colitis models, that is, IBD\u2010mimicking oral dextran sulfate sodium (DSS) exposure and oral\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection. Parp14 was expressed in the human colon by cells in the lamina propria, but, in particular, by the epithelial cells with a granular staining pattern in the cytosol. The same expression pattern was evidenced in both mouse models. Parp14\u2010deficiency caused increased rectal bleeding as well as stronger epithelial erosion, Goblet cell loss, and immune cell infiltration in DSS\u2010exposed mice. The absence of Parp14 did not affect the mouse colon bacterial microbiota. Also, the colon leukocyte populations of Parp14\u2010deficient mice were normal. In contrast, bulk tissue RNA\u2010Seq demonstrated that the colon transcriptomes of Parp14\u2010deficient mice were dominated by abnormalities in inflammation and infection responses both prior and after the DSS exposure. Overall, the data indicate that Parp14 has an important role in the maintenance of colon epithelial barrier integrity. The prognostic and predictive biomarker potential of Parp14 in IBD merits further investigation.\n                  <\/jats:p>","DOI":"10.1096\/fj.202400484r","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T07:00:40Z","timestamp":1720162840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Body\u2010wide genetic deficiency of poly(\n                    <scp>ADP<\/scp>\n                    \u2010ribose) polymerase 14 sensitizes mice to colitis"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-7848","authenticated-orcid":false,"given":"Madhukar","family":"Vedantham","sequence":"first","affiliation":[{"name":"Institute of Biomedicine University of Turku  Turku 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