{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:56:25Z","timestamp":1784804185668,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["MLP2008"],"award-info":[{"award-number":["MLP2008"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite the loss of melanocytes, individuals with vitiligo have a significantly lower risk of developing skin malignancies compared to ethnicity\u2010matched controls. The study investigated the molecular mechanisms that protect skin cells (keratinocytes) from UV\u2010B\u2010induced DNA damage in individuals with vitiligo. The study found that upregulation of stem cell factor (SCF) signaling significantly reduced \u03b3\u2010H2AX positivity and cyclobutane pyrimidine dimer formation and improved mitochondrial health (elongated mitochondria, reduced reactive oxygen species [ROS] and lipid peroxidation) in keratinocytes upon UV\u2010B exposure. Interestingly, SCF treatment also reduced lipid droplet accumulation and triacylglyceride levels by upregulating lipoprotein lipase (LPL). Further, siLPL increased DNA damage and lipid droplet (LD) accumulation, while NO\u20101886, an LPL agonist, reversed both, suggesting a direct link between lipid metabolism and DNA damage. Downregulation of NAD\u2010dependent deacetylase sirtuin1 (SIRT1) with siRNA or with Ex\u2010527, a pharmacological inhibitor of SIRT1, diminished the protective effects mediated by SCF and NO\u20101886, suggesting SIRT1 to be the final effector protein in the SCF\u2010LPL\u2010SIRT1 signaling axis. Analysis of clinical samples of vitiligo corroborated the upregulation of SCF and LPL in lesional epidermis. In conclusion, our study demonstrates a novel SCF\u2010LPL\u2010SIRT1 signaling axis that confers protection to vitiligo keratinocytes from the harmful effects of UV\u2010B radiation.<\/jats:p>","DOI":"10.1096\/fj.202400550r","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T05:16:14Z","timestamp":1732511774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stem cell factor\u2010mediated upregulation of SIRT1 protects melanin\u2010deprived keratinocytes against UV\u2010induced DNA damage in individuals with vitiligo"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6992-7206","authenticated-orcid":false,"given":"Hemang D.","family":"Brahmbhatt","sequence":"first","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3673-8539","authenticated-orcid":false,"given":"Manish","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4826-7989","authenticated-orcid":false,"given":"Rohit","family":"Gupta","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0057-3174","authenticated-orcid":false,"given":"Anshu","family":"Priya","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4181-5398","authenticated-orcid":false,"given":"Akta","family":"Kundu","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-7688","authenticated-orcid":false,"given":"Praveen","family":"Singh","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9569-2729","authenticated-orcid":false,"given":"Sonam","family":"Dhamija","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-8086","authenticated-orcid":false,"given":"Aayush","family":"Gupta","sequence":"additional","affiliation":[{"name":"Dr. D. 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