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Additionally,\n                    <jats:italic>Lactobacillus casei<\/jats:italic>\n                    is a well\u2010known probiotic commonly used in fermentation processes as a starter. The current study aimed to investigate the potential of\n                    <jats:italic>Lactobacillus casei<\/jats:italic>\n                    \u2010fermented\n                    <jats:italic>Amomum xanthioides<\/jats:italic>\n                    (LAX) in alleviating metabolic disorders induced by high\u2010fat diet (HFD) in a mouse model. LAX significantly reduced the body and fat weight, outperforming AX, yet without suppressing appetite. LAX also markedly ameliorated excessive lipid accumulation and reduced inflammatory cytokine (IL\u20106) levels in serum superior to AX in association with UCP1 activation and adiponectin elevation. Furthermore, LAX noticeably improved the levels of fasting blood glucose, serum insulin, and HOMA\u2010IR through positive regulation of glucose transporters (GLUT2, GLUT4), and insulin receptor gene expression. In conclusion, the fermentation of AX demonstrates a pronounced mitigation of overnutrition\u2010induced metabolic dysfunction, including hyperlipidemia, hyperglycemia, hyperinsulinemia, and obesity, compared to non\u2010fermented AX. Consequently, we proposed that the fermentation of AX holds promise as a potential candidate for effectively ameliorating metabolic disorders.\n                  <\/jats:p>","DOI":"10.1096\/fj.202400552r","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T10:05:44Z","timestamp":1715767544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Lactobacillus casei<\/i>\n                    \u2010fermented\n                    <i>Amomum xanthioides<\/i>\n                    ameliorates metabolic dysfunction in\n                    <scp>high\u2010fat<\/scp>\n                    diet\u2010induced obese mice"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-7429","authenticated-orcid":false,"given":"Jing\u2010Hua","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Bioscience &amp; Integrative Medicine Daejeon University  Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-9133","authenticated-orcid":false,"given":"Seung\u2010Ju","family":"Hwang","sequence":"additional","affiliation":[{"name":"Institute of Bioscience &amp; 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