{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:01Z","timestamp":1793831221950,"version":"4.6.1"},"reference-count":61,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/0431"],"award-info":[{"award-number":["PI21\/0431"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI19\/00277"],"award-info":[{"award-number":["FI19\/00277"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["CT58\/21\u2010CT59\/21"],"award-info":[{"award-number":["CT58\/21\u2010CT59\/21"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["CT15\/23"],"award-info":[{"award-number":["CT15\/23"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["CT41\/22\/PEJ\u20102021\u2010AI\/BMD\u201022002"],"award-info":[{"award-number":["CT41\/22\/PEJ\u20102021\u2010AI\/BMD\u201022002"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The association between cardiac fibrosis and galectin\u20103 was evaluated in patients with acute myocardial infarction (MI). The role of galectin\u20103 and its association with endoplasmic reticulum (ER) stress activation in the progression of cardiovascular fibrosis was also evaluated in obese\u2010infarcted rats. The inhibitor of galectin\u20103 activity, modified citrus pectin (MCP; 100\u2009mg\/kg\/day), and the inhibitor of the ER stress activation, 4\u2010phenylbutyric acid (4\u2010PBA; 500\u2009mg\/kg\/day), were administered for 4\u2009weeks after MI in obese rats. Overweight\u2010obese patients who suffered a first MI showed higher circulating galectin\u20103 levels, higher extracellular volume, and LV infarcted size, as well as lower E\/e'ratio and LVEF compared with normal\u2010weight patients. A correlation was observed between galectin\u20103 levels and extracellular volume. Obese\u2010infarcted animals presented cardiac hypertrophy and reduction in LVEF, and E\/A ratio as compared with control animals. They also showed an increase in galectin\u20103 gene expression, as well as cardiac fibrosis and reduced autophagic flux. These alterations were associated with ER stress activation characterized by enhanced cardiac levels of binding immunoglobulin protein, which were correlated with those of galectin\u20103. Both MCP and 4\u2010PBA not only reduced cardiac fibrosis, oxidative stress, galectin\u20103 levels, and ER stress activation, but also prevented cardiac functional alterations and ameliorated autophagic flux. These results show the relevant role of galectin\u20103 in the development of diffuse fibrosis associated with MI in the context of obesity in both the animal model and patients. Galectin\u20103 in tandem with ER stress activation could modulate different downstream mechanisms, including inflammation, oxidative stress, and autophagy.<\/jats:p>","DOI":"10.1096\/fj.202400747r","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T04:59:30Z","timestamp":1720673970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The detrimental role of galectin\u20103 and endoplasmic reticulum stress in the cardiac consequences of myocardial ischemia in the context of obesity"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-4678","authenticated-orcid":false,"given":"Sara","family":"Jim\u00e9nez\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-5964","authenticated-orcid":false,"given":"Beatriz","family":"Delgado\u2010Valero","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-7073","authenticated-orcid":false,"given":"Fabian","family":"Islas","sequence":"additional","affiliation":[{"name":"Unidad de Imagen Card\u00edaca Hospital General Universitario de Talavera de la Reina  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1083-8056","authenticated-orcid":false,"given":"Ana","family":"Romero\u2010Miranda","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9529-9655","authenticated-orcid":false,"given":"Mar\u00eda","family":"Luaces","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda Instituto Cardiovascular, Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-2317","authenticated-orcid":false,"given":"Bunty","family":"Ramchandani","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Cardiaca Infantil Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-568X","authenticated-orcid":false,"given":"Mar\u00eda","family":"Cuesta\u2010Corral","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0754-249X","authenticated-orcid":false,"given":"Alejandro","family":"Montoro\u2010Garrido","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-2041","authenticated-orcid":false,"given":"Ernesto","family":"Mart\u00ednez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Universidad Complutense de Madrid  Madrid Spain"},{"name":"Ciber de Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-6293","authenticated-orcid":false,"given":"Victoria","family":"Cachofeiro","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM) Universidad Complutense de Madrid  Madrid Spain"},{"name":"Ciber de Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36914-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190578"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.995367"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09791"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306565"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.06.025"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46119-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494539"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.032086"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-014-0075-x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300569"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.08.002"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2556-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081167"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111229"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13888"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081274"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.923124"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.10.032"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.249318"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.10.012"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.09.025"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs184"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2018.10.013"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-016-0308-4"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7904"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2024.02.009"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.04.004"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13213348"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023238"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147181.65298.4D"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159682"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.048"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071232"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00422"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.758311"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.112"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118718"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.851941"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.998"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-1017-8"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa133"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.906753"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.917914"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00939-10"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/352794"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.04.014"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0464-4"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.020"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24516"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2018-0100"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4637043"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp088"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2014.08.006"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.05.007"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E18-01-0013"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/827971"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05876"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202400747R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:42:01Z","timestamp":1761694921000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202400747R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,11]]},"references-count":61,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,7,31]]}},"alternative-id":["10.1096\/fj.202400747R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202400747r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,11]]},"assertion":[{"value":"2024-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23818"}}