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Integrins are the main type of cell adhesive molecules in mammals, playing a role in many biological pathways. Although various studies have shown correlations between ITGA7 and various types of cancer, a comprehensive study at a pan\u2010cancer level has not yet been conducted. In this study, we investigated the function of ITGA7 in distinct tumor types using the multi\u2010omics relevant information, then two CeRNA regulatory network was drawn to identify the ITGA7 hub regulatory RNAs. The results indicated that the expression of ITGA7 varies in different tumors. Overexpression of ITGA7 was correlated with a worse OS in BLCA, LGG, and UVM, and the downregulation of ITGA7 was related to a worse OS in PAAD. In addition, BLCA, and UVM showed poor PFS in association with ITGA7 overexpression, and PAAD, SARC, and THCA indicated poor PFS in correlation with ITGA7 under expression. Further analyses of ITGA7 gene alteration data showed that ITGA7 amplifications may have an impact on Kidney Chromophobe prognosis. In 20 types of tumors, ITGA7 expression was linked to cancer\u2010associated fibroblast infiltration. ITGA7 expression was linked to cancer\u2010associated fibroblast infiltration. ITGA7\u2010Related Gene Enrichment Analysis indicated that ITGA7 expression\u2010correlated and functional binding genes were enriched in homotypic cell\u2013cell adhesion, focal adhesion, and ECM\u2010receptor interaction. This pan\u2010cancer study found that abnormal expression of ITGA7 was correlated with poor prognosis and metastasis in different types of tumors. Thus, the ITGA7 gene may prove to be a promising biomarker for the prognosis and complication prevention of different cancers.<\/jats:p>","DOI":"10.1096\/fj.202400917r","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T11:14:19Z","timestamp":1728299659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The pan\u2010cancer landscape presented\n                    <scp>ITGA7<\/scp>\n                    as a prognostic determinant, tumor suppressor, and oncogene in multiple tumor types"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-1510","authenticated-orcid":false,"given":"Mahboobeh","family":"Zarei","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-4217","authenticated-orcid":false,"given":"Fatemeh","family":"Sadri","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Medicine, School of Medicine Zanjan University of Medical Science  Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-6009","authenticated-orcid":false,"given":"Amirhossein","family":"Mohajeri\u00a0Khorasani","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine Hormozgan University of Medical Sciences  Bandar Abbas Iran"},{"name":"Molecular Medicine Research Center, Hormozgan Health Institute Hormozgan University of Medical Sciences  Bandar Abbas Iran"},{"name":"Student Research Committee Hormozgan University of Medical Sciences  Bandar Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9185-1049","authenticated-orcid":false,"given":"MohammadReza","family":"Mirinezhad","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Molecular Medicine, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-7561","authenticated-orcid":false,"given":"Pegah","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center, Hormozgan Health Institute Hormozgan University of Medical Sciences  Bandar Abbas Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.881801"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S160379"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.05.010"},{"key":"e_1_2_12_6_1","unstructured":"LuoJ.Integrin alpha 7 mutations in prostate cancer liver cancer glioblastoma multiforme and leiomyosarcoma. 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