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Blood feeding in the female\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    mosquito is essential for egg maturation and for transmission of disease agents between human subjects. Here, we identify the\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    sulfakinin receptor gene\n                    <jats:italic>SKR<\/jats:italic>\n                    from the\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    genome and show that\n                    <jats:italic>SKR<\/jats:italic>\n                    is expressed at different developmental stages and in varied anatomical localizations in the adult mosquito (at three days after eclosion), with particularly high expression in the CNS. Knockingdown sulfakinin and sulfakinin receptor gene expression in the female\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    results in increased blood meal intake, but microinjection in the thorax of the sulfakinin peptide 1 and 2 both inhibits dose dependently blood meal intake (and delays the time course of blood intake), which is reversible with receptor antagonist. Sulfakinin receptor expressed ectopically in mammalian cells CHO\u2010K1 responds to sulfakinin stimulation with persistent calcium spikes, blockable with receptor antagonist. These data together suggest that activation of the Gq protein\u2010coupled (i.e., calcium\u2010mobilizing) sulfakinin receptor inhibits blood meal intake in female\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    mosquitoes and could serve as a strategic node for the future control of\n                    <jats:italic>A. aegypti<\/jats:italic>\n                    mosquito reproduction\/population and disease transmission.\n                  <\/jats:p>","DOI":"10.1096\/fj.202401165r","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:07:52Z","timestamp":1723010872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Activation of the G protein\u2010coupled sulfakinin receptor inhibits blood meal intake in the mosquito\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1096","volume":"38","author":[{"given":"Linlong","family":"Jiang","sequence":"first","affiliation":[{"name":"Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences Hainan University  Haikou Hainan China"},{"name":"Hainan Province Key Laboratory of One Health Collaborative Innovation Center of One Health Hainan University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Bing","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Life Sciences Beijing Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences Hainan University  Haikou Hainan China"},{"name":"Hainan Province Key Laboratory of One Health Collaborative Innovation Center of One Health Hainan University  Haikou Hainan China"},{"name":"Hainan International One Health Institute Hainan University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences Hainan University  Haikou Hainan China"},{"name":"Hainan Province Key Laboratory of One Health Collaborative Innovation Center of One Health Hainan University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life Sciences Hainan University  Haikou Hainan China"},{"name":"Hainan Province Key Laboratory of One Health Collaborative Innovation Center of One Health Hainan University  Haikou Hainan 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