{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:35:48Z","timestamp":1787009748891,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.507173\/2020\u201000"],"award-info":[{"award-number":["88887.507173\/2020\u201000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["BPD\u201001010\u201022"],"award-info":[{"award-number":["BPD\u201001010\u201022"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201003221\u201018"],"award-info":[{"award-number":["APQ\u201003221\u201018"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["PQ\u2010310799\/2022\u20108"],"award-info":[{"award-number":["PQ\u2010310799\/2022\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    is a frequent cause of antimicrobial\u2010resistant hospital\u2010acquired pneumonia, especially in critically ill patients. Inflammation triggered by\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    infection is necessary for bacterial clearance but must be spatially and temporally regulated to prevent further tissue damage and bacterial dissemination. Emerging data have shed light on the pro\u2010resolving actions of angiotensin\u2010(1\u20107) [Ang\u2010(1\u20107)] signaling through the G protein\u2010coupled receptor Mas (MasR) during infections. Herein, we investigated the role of the Ang\u2010(1\u20107)\/Mas axis in pneumonia caused by\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    by using genetic and pharmacological approach and found that Mas receptor\u2010deficient animals developed a more severe form of pneumonia showing higher neutrophilic infiltration into the airways, bacterial load, cytokines, and chemokines production and more severe pulmonary damage. Conversely, treatment of pseudomonas\u2010infected mice with Ang\u2010(1\u20107) was able to decrease neutrophilic infiltration in airways and lungs, local and systemic levels of pro\u2010inflammatory cytokines and chemokines, and increase the efferocytosis rates, mitigating lung damage\/dysfunction caused by infection. Notably, the therapeutic association of Ang\u2010(1\u20107) with antibiotics improved the survival rates of mice subjected to lethal inoculum of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , extending the therapeutic window for imipenem. Mechanistically, Ang\u2010(1\u20107) increased phagocytosis of bacteria by neutrophils and macrophages to accelerate pathogen clearance. Altogether, harnessing the Ang\u2010(1\u20107) pathway during infection is a potential strategy for the development of host\u2010directed therapies to promote mechanisms of resistance and resilience to pneumonia.\n                  <\/jats:p>","DOI":"10.1096\/fj.202401178r","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T12:28:53Z","timestamp":1726230533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The angiotensin\u2010(1\u20107)\/\n                    <scp>MasR<\/scp>\n                    axis improves pneumonia caused by\n                    <i>Pseudomonas aeruginosa<\/i>\n                    : Extending the therapeutic window for antibiotic therapy"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-8814","authenticated-orcid":false,"given":"Isabella","family":"Zaidan","sequence":"first","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6185-274X","authenticated-orcid":false,"given":"Ant\u00f4nio Felipe Silva","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Unidade Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais\/Ebserh  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0992-3043","authenticated-orcid":false,"given":"La\u00eds C.","family":"Grossi","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3775-7333","authenticated-orcid":false,"given":"J\u00e9ssica A. M.","family":"Souza","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6791-2189","authenticated-orcid":false,"given":"Edvaldo S.","family":"Lara","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-4838","authenticated-orcid":false,"given":"Ana Clara M.","family":"Montuori\u2010Andrade","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-579X","authenticated-orcid":false,"given":"Camila","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-1519","authenticated-orcid":false,"given":"Fernanda S.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte 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Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7688-7505","authenticated-orcid":false,"given":"Isabella de Lacerda","family":"Augusto","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0387-0919","authenticated-orcid":false,"given":"Rodrigo Severo","family":"Caixeta","sequence":"additional","affiliation":[{"name":"Signaling in Inflammation Laboratory, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Belo Horizonte 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Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-5013","authenticated-orcid":false,"given":"Leonardo Camilo","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofarmacologia, Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-7709","authenticated-orcid":false,"given":"Celso Martins","family":"Queiroz\u2010Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofarmacologia, Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-3834","authenticated-orcid":false,"given":"Remo C.","family":"Russo","sequence":"additional","affiliation":[{"name":"Laboratory of Pulmonary Immunology and Mechanics, Departamento de Fisiologia e Biof\u00edsica, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-4206","authenticated-orcid":false,"given":"Maria Jos\u00e9","family":"Campagnole\u2010Santos","sequence":"additional","affiliation":[{"name":"National Institute in Science and Technology in nanobiopharmaceutics, Departamento de Fisiologia e Biof\u00edsica, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte 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S.","family":"Santos","sequence":"additional","affiliation":[{"name":"National Institute in Science and Technology in nanobiopharmaceutics, Departamento de Fisiologia e Biof\u00edsica, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-642X","authenticated-orcid":false,"given":"Vivian V.","family":"Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofarmacologia, Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-5934","authenticated-orcid":false,"given":"Daniele da Gl\u00f3ria","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofarmacologia, Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Laborat\u00f3rio de Intera\u00e7\u00e3o Microrganismo\u2010Hospedeiro, Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-5233","authenticated-orcid":false,"given":"Caio T.","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofarmacologia, Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Laborat\u00f3rio de Intera\u00e7\u00e3o Microrganismo\u2010Hospedeiro, Departamento de 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