{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:36:09Z","timestamp":1787009769136,"version":"build-2736575974"},"reference-count":76,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304205"],"award-info":[{"award-number":["2022YFC2304205"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471791"],"award-info":[{"award-number":["82471791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304574"],"award-info":[{"award-number":["82304574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["202301\u2010404"],"award-info":[{"award-number":["202301\u2010404"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Malaria remains a significant global public health problem. T follicular helper (Tfh) cells, a subset of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, have the capacity to regulate B cells, plasma cells, and antibody production, among other functions. Myeloid\u2010derived suppressor cells (MDSCs) possess strong immunosuppressive abilities and can negatively regulate various immune responses. However, the role of MDSCs in inhibiting Tfh\u2010cell responses during\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection remains unclear. In this study, we investigated the regulatory effect of MDSCs on Tfh cell\u2010mediated immune responses upon\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection. We found that the numbers of MDSCs increased upon\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection. Further mechanism study revealed that MDSC\u2010derived Arg\u20101 and PD\u2010L1 prevented Tfh cell proliferation and activation. Conversely, the addition of nor\u2010NOHA or anti\u2010PD\u2010L1 monoclonal antibodies enhanced the proliferation and activation of Tfh cells, indicating that the inhibitory effect of MDSCs on Tfh cells was dependent on Arg\u20101 and PD\u20101\/PD\u2010L1. In\u00a0vivo depletion of MDSCs enhanced Tfh\u2010cell responses and antibody production, as well as relieved symptoms of infected mice and improved their survival rates. These findings provide insights into the immunosuppressive role of MDSCs in inhibiting Tfh cell immune responses and further impairing humoral immunity. Our study provides new strategies for malaria prevention and control.\n                  <\/jats:p>","DOI":"10.1096\/fj.202401237r","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T06:15:28Z","timestamp":1733292928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myeloid\u2010derived suppressor cells inhibit responses of T follicular helper cells during experimental\n                    <i>Plasmodium yoelii<\/i>\n                    infection"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3086-4882","authenticated-orcid":false,"given":"Lengshan","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology and Immunology, Sino\u2010French Hoffmann Institute, School of Basic Medical Sciences Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8459-1017","authenticated-orcid":false,"given":"Cansheng","family":"Hong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1112-4653","authenticated-orcid":false,"given":"Zhihan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou National Laboratory Guangzhou International Bio\u2010Island  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-2056","authenticated-orcid":false,"given":"Yanwei","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology, Sino\u2010French Hoffmann Institute, School of Basic Medical Sciences Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaina","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizhen","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou National Laboratory Guangzhou International Bio\u2010Island  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4146-9441","authenticated-orcid":false,"given":"Peibin","family":"Lin","sequence":"additional","affiliation":[{"name":"Affiliated Qingyuan Hospital Guangzhou Medical University, Qingyuan People's Hospital  Qingyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9665-9322","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Basic Medical Sciences Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-4221","authenticated-orcid":false,"given":"Xiancai","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou National Laboratory Guangzhou International Bio\u2010Island  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-6862","authenticated-orcid":false,"given":"Quan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathogenic Biology and Immunology, Sino\u2010French Hoffmann Institute, School of Basic Medical Sciences Guangzhou Medical University  Guangzhou China"},{"name":"State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy &amp; Clinical Immunology The Second Affiliated Hospital, Guangzhou Medical University  Guangzhou China"},{"name":"Affiliated Qingyuan Hospital Guangzhou Medical University, Qingyuan People's Hospital  Qingyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.30875\/6c551ba0-en"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025619"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-02052-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1686"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-19"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0158-z"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701316"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.02.071"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.09.004"},{"key":"e_1_2_11_11_1","article-title":"CD4 T\u2010cell subsets in malaria: TH1\/TH2 revisited","volume":"5","author":"Perez\u2010Mazliah D","year":"2014","journal-title":"Front Immunol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01597"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004715"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv057"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.144"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0022-x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00670-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0764"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.01.004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104254"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00037"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303408"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400196"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601860"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155910"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.625712"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300541"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328354b43f"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI136288"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-020-00920-5"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21756"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02499"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.12.004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-021-05006-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700671"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0678-5"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2455-6"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74056"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-014-1598-8"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1784"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac090"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.04.001"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3690"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00490-y"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110671"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12835"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061395"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12929"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020775"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.08.030"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006484"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4RI0515-204R"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68189"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.09.016"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.12.014"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.02.036"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4467"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006054"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124080"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1348"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1086\/592971"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005118"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-024-02463-3"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101621"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1383456"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403206"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02926"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12860"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055605"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900500"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051468"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111275"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.189024"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01254-7"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.02.002"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01253-8"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202401237R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:59:52Z","timestamp":1761681592000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202401237R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":76,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2024,12,15]]}},"alternative-id":["10.1096\/fj.202401237R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202401237r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"2024-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70211"}}