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Especially, the development and healing of diabetic foot ulcers (DFUs) remain an urgent clinical problem. The human gut harbors a vast microbial ecosystem comprising intestinal flora and their metabolic products. Recent advancements in research have illuminated the concept of the \u201cgut\u2010skin axis,\u201d revealing intricate relationships between gut microbiota, microbiota\u2010derived metabolites, and various skin diseases, including DFUs. This review aims to unravel the formation and healing process of DFUs in the context of the gut\u2010skin axis. We reviewed the current research progress worldwide regarding to the gut\u2010skin axis, compared and discussed significant changes in the microbiota colonizing the skin and gut in patients with DFUs. The roles of microbiota\u2010derived metabolites such as lipopolysaccharides, short\u2010chain fatty acids, and trimethylamine\u2010N\u2010oxide in the development of DFUs are highlighted. 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