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For example, human intestinal microbe\n                    <jats:italic>Limosilactobacillus reuteri<\/jats:italic>\n                    strains ATCC PTA 6475 and DSM 17938 are being considered for use for intestinal ailments, including colic, infection, and inflammation, as well as for non\u2010intestinal ailments, including osteoporosis, wound healing, and autism spectrum disorder. While many of their beneficial properties are attributed to suppressing inflammatory responses, we postulated that\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    may also regulate intestinal hormones to affect physiology within and outside of the gut. To determine if\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    secreted factors impact the secretion of enteric hormones, we treated an engineered jejunal organoid line,\n                    <jats:italic>NGN3<\/jats:italic>\n                    \u2010HIO, which can be induced to be enriched in enteroendocrine cells, with\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    6475 or 17938 conditioned medium and performed transcriptomics. Our data suggest that these\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    strains affect the transcription of many gut hormones, including vasopressin and luteinizing hormone subunit beta, which have not been previously recognized as produced in the gut epithelium. Moreover, we find that these hormones appear to be produced in enterocytes, in contrast to canonical gut hormones produced in enteroendocrine cells. Finally, we show that\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    conditioned media promote the secretion of enteric hormones, including serotonin, GIP, PYY, vasopressin, and luteinizing hormone subunit beta, and identify by metabolomics metabolites potentially mediating these effects on hormones. These results support\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    affecting host physiology through intestinal hormone secretion, thereby expanding our understanding of the mechanistic actions of this microbe.\n                  <\/jats:p>","DOI":"10.1096\/fj.202401669r","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T04:02:04Z","timestamp":1742270524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Limosilactobacillus reuteri<\/i>\n                    promotes the expression and secretion of enteroendocrine\u2010 and enterocyte\u2010derived hormones"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6188-663X","authenticated-orcid":false,"given":"Sara C.","family":"Di Rienzi","sequence":"first","affiliation":[{"name":"Department of Molecular Virology and Microbiology Baylor College of Medicine  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