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We aimed here to evaluate the chemokine CXCL14, as a novel biomarker in acute viral hepatitis. We used a mouse model of acute hepatitis induced by murine hepatitis virus (MHV), a hepatotropic and lytic coronavirus, and showed that CXCL14 is overexpressed in the liver and sera of infected mice. Using primary cultures of murine and human hepatocytes, we showed that hepatocytes are the main source of CXCL14 after lytic hepatotropic virus infection and that CXCL14 expression is also induced by the pro\u2010inflammatory cytokines IL\u20106 and TNF\u03b1. CXCL14 KO mice infected with MHV were partially protected and showed an attenuated antiviral immune response compared to wild\u2010type mice. Finally, we show that CXCL14 is overexpressed in the sera of human patients infected with hepatitis viruses A, B, and E or herpes simplex virus. A positive correlation between CXCL14 and ALT levels in the sera of patients with acute herpetic hepatitis, as well as in mice models, suggests that hepatocyte lysis is necessary for the release of CXCL14. Overall, these data highlight that CXCL14 expression is associated with the occurrence of acute viral hepatitis and could be considered an alarmin and a new indicator of inflammation. CXCL14 serum levels are also associated with the severity of viral\u2010induced liver injury.<\/jats:p>","DOI":"10.1096\/fj.202401706r","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:25:23Z","timestamp":1747733123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CXCL14<\/scp>\n                    Chemokine Exacerbates Acute Viral Hepatitis in Coronavirus\n                    <scp>MHV<\/scp>\n                    \u2010Infected Mice and Is Associated With Human Acute Viral Hepatitis"],"prefix":"10.1096","volume":"39","author":[{"given":"Christelle","family":"Devisme","sequence":"first","affiliation":[{"name":"University of Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail)\u2014UMR_S 1085  Rennes France"},{"name":"Institute of Virology and Immunology  Mittelh\u00e4usern Switzerland"},{"name":"Department of Infectious Diseases 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