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Circular RNA (circRNA), a novel type of endogenous RNA molecule with a covalently closed circular structure through \u201cback\u2010splicing,\u201d is reported to be widely present in eukaryotic cells and participates mainly in regulating gene and protein expression in various ways. It is becoming a research hotspot in the non\u2010coding RNA field. CircRNA shows close relation to several varieties of autoimmune diseases (AIDs) in both the physiological and pathological level and could potentially be used clinically in terms of diagnosis and treatment. Here, we focus on reviewing the importance of circRNA in various AIDs, with the aim of establishing new biomarkers and providing novel insights into understanding the role and functions of circRNA in AIDs. Specific signaling pathways of how circular RNAs are regulated in AIDs will also be illustrated in this review.<\/jats:p>","DOI":"10.1096\/fj.202401764r","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T09:31:00Z","timestamp":1738056660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of circular\n                    <scp>RNAs<\/scp>\n                    in autoimmune diseases: Potential diagnostic biomarkers and therapeutic targets"],"prefix":"10.1096","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-908X","authenticated-orcid":false,"given":"Xin\u2019ai","family":"Li","sequence":"first","affiliation":[{"name":"Dongzhimen Hospital Beijing University of Chinese Medicine  Beijing China"},{"name":"Tongchuan City Thyroid Disease Prevention Center  Tongchuan 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