{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:55:56Z","timestamp":1787500556064,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101698"],"award-info":[{"award-number":["82101698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH020"],"award-info":[{"award-number":["ZR2022MH020"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2022\u201006\u201040"],"award-info":[{"award-number":["320.6750.2022\u201006\u201040"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011482","name":"Yantai Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022JCYJ039"],"award-info":[{"award-number":["2022JCYJ039"]}],"id":[{"id":"10.13039\/501100011482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011482","name":"Yantai Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023YD004"],"award-info":[{"award-number":["2023YD004"]}],"id":[{"id":"10.13039\/501100011482","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Decidualization of endometrial stromal cells is a prerequisite for successful embryo implantation and early pregnancy. Decidualization dysregulation results in implantation failure. In our previous study, we reported that PAI\u20101 is abnormally downregulated in the endometrial tissue samples of patients with recurrent implantation failure. This study will explore the dynamic expression changes of PAI\u20101 in the endometrium during the menstrual cycle and its molecular mechanism affecting endometrial decidualization. Our findings indicated that the abundance of PAI\u20101 increased in the mid\u2010secretory phase and attached a peak in the decidual phase in the endometrium of women with regular menstrual cycles. In human endometrial stromal cells (HESCs), PAI\u20101 knockdown attenuated endometrial decidualization by upregulating VEGFR2\/PI3K\/AKT signaling pathway and impaired the F\u2010actin reorganization. Furthermore, axitinib (a VEGFR2 inhibitor) was used to inhibit the VEGFR2 protein activity and the results suggested that it eliminated the effects of PAI\u20101 on PI3K\/AKT signaling pathways and F\u2010actin remodeling. In addition, the interaction between PAI\u20101 and KNG1 was confirmed by coimmunoprecipitation assay in HESCs. Altogether, PAI\u20101\u2010KNG1 may enhance the decidualization of endometrium by inhibiting VEGFR2\/PI3K\/AKT signaling pathway\u2010mediated F\u2010actin reorganization in healthy females.<\/jats:p>","DOI":"10.1096\/fj.202401882r","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T09:30:01Z","timestamp":1735032601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>PAI<\/scp>\n                    \u20101 promotes human endometrial stromal decidualization via inhibiting\n                    <scp>VEGFR2<\/scp>\n                    \/\n                    <scp>PI3K<\/scp>\n                    \/\n                    <scp>AKT<\/scp>\n                    signaling\u00a0pathway mediated F\u2010actin reorganization"],"prefix":"10.1096","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-4816","authenticated-orcid":false,"given":"Huishan","family":"Zhao","sequence":"first","affiliation":[{"name":"The Affiliated Yantai Yuhuangding Hospital of Qingdao University  Yantai China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Reproductive Health and Genetics (Yantai Yuhuangding Hospital)  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3876-9874","authenticated-orcid":false,"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Central Laboratory The Affiliated Yantai Yuhuangding Hospital of Qingdao University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4341-514X","authenticated-orcid":false,"given":"Shuyuan","family":"Yin","sequence":"additional","affiliation":[{"name":"The Affiliated Yantai Yuhuangding Hospital of Qingdao University  Yantai China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Reproductive Health and Genetics (Yantai Yuhuangding Hospital)  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-5484","authenticated-orcid":false,"given":"Hongchu","family":"Bao","sequence":"additional","affiliation":[{"name":"The Affiliated Yantai Yuhuangding Hospital of Qingdao University  Yantai China"},{"name":"Shandong Provincial Key Medical and Health Laboratory of Reproductive Health and Genetics (Yantai Yuhuangding Hospital)  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.011"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1045"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12091275"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061973"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114092"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac007"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-023-02946-1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw004"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/107155760200900602"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.113851"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31820bf288"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0698-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00147.2010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00623-1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12516"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103490"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.01.018"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.11.025"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.074666"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.111987"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae111"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab303"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304554"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.4.1823"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07442"},{"key":"e_1_2_12_27_1","first-page":"280","article-title":"Elevated levels of serum vascular endothelial growth factor\u2010a are not related to NK cell parameters in recurrent IVF failure","volume":"18","author":"Bansal R","year":"2017","journal-title":"J Reprod Infertil"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0109"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186520"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15190"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010622"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.04.012"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.02.014"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.004"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/3.9.781"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah081"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-017-0243-8"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.3.0334"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041630105"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2000.0135"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.2741\/1001"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12360"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0127-8"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm1896"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.10.024"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa337"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177387"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.304972"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23375"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010382"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0833-0"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2023.2271260"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611327200"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202401882R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202401882R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202401882R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:28:23Z","timestamp":1776508103000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202401882R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":52,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,12,31]]}},"alternative-id":["10.1096\/fj.202401882R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202401882r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,24]]},"assertion":[{"value":"2024-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70233"}}